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Table 3 Group comparison results for significant NPS

From: White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

NPS

P-value

Agitation

 FTD (39.2%) > PD (17.4%)

0.003

Anxiety

 FTD (47.1%) > PD (21.7%)

0.001

 FTD (47.1%) > ALS (17.5%)

0.004

 FTD (47.1%) > CVD (15.2%)

 < 0.001

 AD/MCI (25.6%) > CVD (15.2%)

0.043†

Apathy

 FTD (56.0%) > PD (23.2%)

 < 0.001

 FTD (56.0%) > ALS (27.5%)

0.001

 FTD (56.0%) > CVD (22.8%)

 < 0.001

 AD/MCI (38.3%) > PD (23.2%)

0.013†

 AD/MCI (38.3%) > CVD (22.8%)

0.009†

Appetite

 FTD (56.9%) > AD/MCI (28.1%)

 < 0.001

 FTD (56.9%) > PD (27.5%)

 < 0.001

 FTD (56.9%) > CVD (22.8%)

 < 0.001

 ALS (41.0%) > CVD (22.8%)

0.026†

Disinhibition

 FTD (44.0%) > CVD (14.5%)

 < 0.001

 FTD (44.0%) > PD (12.3%)

 < 0.001

 FTD (44.0%) > ALS (7.5%)

 < 0.001

 AD/MCI (23.1%) > PD (12.3%)

0.030†

 AD/MCI (23.1%) > ALS (7.5%)

0.036†

Euphoria

 FTD (15.7%) > PD (2.9%)

 < 0.001

Irritability

 FTD (58.8%) > PD (27.5%)

 < 0.001

 FTD (58.8%) > ALS (22.5%)

 < 0.001

Aberrant motor behaviour

 FTD (31.4%) > CVD (8.3%)

 < 0.001

 FTD (31.4%) > PD (5.1%)

 < 0.001

 AD/MCI (12.8%) > PD (5.1%)

0.042†

Night time behaviours

 FTD (54.9%) > AD/MCI (22.8%)

 < 0.001

 PD (52.9%) > ADMCI (22.8%)

 < 0.001

  1. Comparisons calculated according to Fisher’s exact test
  2. AD Alzheimer’s disease, ALS Amyotrophic lateral sclerosis, CVD Cerebrovascular disease, FTD Frontotemporal disease, MCI Mild cognitive impairment, NPS Neuropsychiatric symptoms, PD Parkinson’s disease
  3. † Did not survive correction for multiple comparisons (0.05/10 = 0.005)