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Table 2 Frequency of NPS across groups

From: White matter hyperintensities and smaller cortical thickness are associated with neuropsychiatric symptoms in neurodegenerative and cerebrovascular diseases

NPS, n (% yes)

AD/MCI

ALS

FTD

PD

CVD

χ 2, p-value

Delusions

10 (8.7)

1 (2.5)

7 (13.7)

4 (2.9)

11 (7.6)

χ 2 (4) = 9.12, p = 0.058‡

Hallucinations

5 (4.3)

1 (2.5)

2 (3.9)

13 (9.5)

3 (2.1)

χ 2 (4) = 9.33, p = 0.053‡

Agitation/aggression

33 ( 28.2)

9 (22.5)

20 (39.2)

24 (17.4)

37 (25.5)

χ 2 (4) = 10.54, p = 0.032*

Depression/dysphoria

38 (32.5)

15 (37.5)

18 (36.0)

52 (37.7)

38 (26.2)

χ 2 (4) = 4.98, p = 0.289

Anxiety

30 (25.6)

7 (17.5)

24 (47.1)

30 (21.7)

22 (15.2)

χ 2 (4) = 22.94, p < 0.001***

Euphoria/elation

6 (5.1)

2 (5.0)

8 (15.7)

4 (2.9)

5 (3.4)

χ 2 (4) = 14.03, p = 0.007**

Apathy/indifference

44 (38.3)

11 (27.5)

28 (56.0)

32 (23.2)

33 (22.8)

χ 2 (4) = 26.43, p < 0.001***

Disinhibition

27 (23.1)

3 (7.5)

22 (44.0)

17 (12.3)

21 (14.5)

χ 2 (4) = 31.62, p < 0.001***

Irritability/lability

44 (37.9)

9 (22.5)

30 (58.8)

38 (27.5)

55 (38.2)

χ 2 (4) = 19.48, p < 0.001***

Aberrant motor behaviour

15 (12.8)

5 (12.8)

16 (31.4)

7 (5.1)

12 (8.3)

χ 2 (4) = 27.68, p < 0.001***

Appetite/eating abnormalities

32 (28.1)

16 (41.0)

29 (56.9)

38 (27.5)

33 (22.8)

χ 2 (4) = 23.79, p < 0.001***

Night time behaviour

26 (22.8)

10 (26.3)

28 (54.9)

73 (52.9)

49 (34.0)

χ 2 (4) = 33.38, p < 0.001***

  1. AD Alzheimer’s disease, ALS Amyotrophic lateral sclerosis, CVD Cerebrovascular disease, FTD Frontotemporal disease, MCI Mild cognitive impairment, NPS Neuropsychiatric symptoms, PD Parkinson’s disease
  2. ‡Trending
  3. ***p < 0.001
  4. **p < 0.01
  5. *p < 0.05