Fig. 4
Associations between polygenic risk scores for Alzheimer’s disease and white matter microstructural MRI metrics. A Barcharts of variance explained by AD PRS (R2, y-axis) constructed at each of eight p-value thresholds (x-axis) for two white matter metrics (FA, fractional anisotropy; MD, mean diffusivity) measured at 10 major white matter tracts: ifo, inferior fronto-occipital fasciculus; ilf, inferior longitudinal fasciculus; slf, superior longitudinal fasciculus; unc, uncinate fasciculus; fma, forceps major; fmi, forceps minor; cgc, cingulate gyrus part of cingulum; cgh, parahippocampal part of cingulum; atr, anterior thalamic radiation; cst, corticospinal tract. Red and blue colors respectively correspond to positive and negative associations. Asterisks indicate p-values after FDR correction: *FDR < 0.05, **FDR < 0.01, ***FDR < 0.001. B White matter t-maps representing t-values of association between AD PRS (at p-value threshold = 5e − 6) and main white matter tracts. Tracts where the association with PRS is significant after FDR correction are shown (FDR value < 5%). Abbreviations: ABCD, Adolescent Brain Cognitive Development Study; UKB, UK Biobank; FA, fractional anisotropy; MD, mean diffusivity; PT, p-value thresholds; PRS, polygenic risk scores