Table 3 Drugs with claim count differences where adjusted P value is lower than 0.05
Drug name | Total matched pairs | Drug users—mean AD claim count | Non-users—mean AD claim count | Paired T-test statistic | Raw P value | Inflation-adjusted P value | Corrected P value | Drug description |
|---|---|---|---|---|---|---|---|---|
Decreased healthcare utilization | ||||||||
Penicillin V | 2635 | 3.93 | 4.63 | − 4.23 | 2.34E − 05 | 3.28E − 03 | 1.98E − 01 | Antibiotic |
Donepezil | 22,005 | 4.16 | 4.44 | − 4.15 | 3.40E − 05 | 3.96E − 03 | 1.98E − 01 | Treats AD |
Sodium sulfate | 6218 | 4.03 | 4.51 | − 3.90 | 9.55E − 05 | 6.68E − 03 | 2.40E − 01 | Laxative |
Clavulanate | 10,721 | 4.16 | 4.52 | − 3.45 | 5.72E − 04 | 1.66E − 02 | 4.75E − 01 | Antibiotic supp |
Albuterol | 9806 | 4.18 | 4.53 | − 3.32 | 8.95E − 04 | 2.09E − 02 | 4.96E − 01 | Asthma |
Sodium chloride | 5789 | 4.03 | 4.43 | − 3.23 | 1.24E − 03 | 2.48E − 02 | 4.96E − 01 | Electrolyte |
Celecoxib | 2629 | 4.01 | 4.60 | − 3.17 | 1.56E − 03 | 2.79E − 02 | 5.06E − 01 | Inflammation |
Amoxicillin | 18,298 | 4.22 | 4.45 | − 2.94 | 3.28E − 03 | 4.10E − 02 | 6.52E − 01 | Antibiotic |
Potassium chloride | 11,608 | 4.20 | 4.45 | − 2.92 | 3.50E − 03 | 4.24E − 02 | 6.52E − 01 | Electrolyte |
Increased healthcare utilization | ||||||||
Quetiapine | 5379 | 5.12 | 4.36 | 5.33 | 1.01E − 07 | 2.14E − 04 | 4.28E − 02 | Schizophrenia |
Valproate | 1643 | 5.30 | 4.19 | 4.48 | 7.63E − 06 | 1.86E − 03 | 1.86E − 01 | Seizures |
Lorazepam | 7199 | 4.82 | 4.36 | 3.87 | 1.11E − 04 | 7.21E − 03 | 2.40E − 01 | Seizures |
Trazodone | 5538 | 4.73 | 4.29 | 3.29 | 1.02E − 03 | 2.24E − 02 | 4.96E − 01 | Anti-depressant |