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Table 1 Drugs where the inflation-adjusted P value was less than 0.05

From: Association study between drug prescriptions and Alzheimer’s disease claims in a commercial insurance database

Drug name

Hazard ratios

Raw P value

Lower CI

Upper CI

Total matched pairs

Drug users with AD

Non-users with AD

Inflation-adjusted P value

Corrected P value

Drug description

Drugs with low hazard ratios

 Amoxicillin

0.44

2.55E − 16

0.36

0.54

27,570

144

325

1.67E − 07

1.67E − 05

Antibiotic

 Azithromycin

0.51

2.51E − 11

0.42

0.62

27,276

152

295

2.11E − 05

1.05E − 03

Antibiotic

 Methylprednisolone

0.51

2.48E − 10

0.41

0.63

24,723

132

259

5.50E − 05

2.20E − 03

Inflammation

 Doxycycline

0.52

3.41E − 08

0.41

0.66

21,268

110

210

4.36E − 04

1.25E − 02

Antibiotic

 Prednisone

0.58

1.73E − 07

0.48

0.71

26,539

150

256

8.66E − 04

2.17E − 02

Inflammation

 Sodium sulfate

0.53

1.25E − 06

0.41

0.69

22,539

90

169

2.01E − 03

4.11E − 02

Laxative

 Clavulanate

0.60

1.66E − 06

0.49

0.74

26,156

143

237

2.26E − 03

4.11E − 02

Antibiotic supp

 Cephalexin

0.63

9.70E − 06

0.51

0.77

23,061

149

236

4.81E − 03

6.93E − 02

Antibiotic

 Magnesium sulfate

0.44

9.90E − 06

0.31

0.63

12,507

42

95

4.85E − 03

6.93E − 02

Electrolyte

 Acetaminophen

0.64

3.15E − 05

0.52

0.79

23,245

140

219

7.98E − 03

9.42E − 02

Analgesic

 Hydrocodone

0.66

3.18E − 05

0.54

0.80

27,112

165

250

8.01E − 03

9.42E − 02

Opioid

 Ibuprofen

0.60

1.48E − 04

0.46

0.78

17,714

86

144

1.56E − 02

1.73E − 01

Inflammation

 Promethazine

0.62

9.24E − 04

0.47

0.82

13,467

80

128

3.47E − 02

3.41E − 01

Antihistamine

 Benzonatate

0.65

9.89E − 04

0.50

0.84

17,534

97

149

3.58E − 02

3.41E − 01

Cough

 Fluticasone

0.72

2.10E − 03

0.58

0.89

22,056

148

206

4.99E − 02

4.47E − 01

Steroid

Drugs with high hazard ratios

 Donepezil

30.70

6.85E − 24

15.78

59.76

1067

235

9

0.00E + 00

0.00E + 00

Treats AD

 Memantine

38.97

5.39E − 13

14.41

105.39

544

132

4

4.25E − 06

2.84E − 04

Treats AD

 Quetiapine

7.19

3.09E − 08

3.58

14.46

1004

63

9

4.18E − 04

1.25E − 02

Antipsychotic

 Sertraline

2.39

1.62E − 06

1.67

3.42

4710

102

43

2.24E − 03

4.11E − 02

SSRI/anxiety

 Trazodone

2.37

6.08E − 06

1.63

3.45

5524

92

39

3.94E − 03

6.56E − 02

Depression

 Escitalopram

3.26

2.08E − 05

1.89

5.61

3830

55

17

6.68E − 03

8.91E − 02

SSRI/anxiety

 Mirtazapine

3.11

2.31E − 04

1.70

5.68

1544

43

14

1.89E − 02

1.99E − 01

Depression

  1. Top table displays the drugs with low hazard ratios, while the bottom table presents drugs with high hazard ratios. Each row displays the drug name, hazard ratios and the 95% confidence intervals, calculated p-values (raw, inflation-adjusted, and corrected), total number of pairs and the number of members with AD in each group, and a brief description of the drug
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Alzheimer's Research & Therapy

ISSN: 1758-9193