Fig. 2

Global network measures as a function of temporal delay across the AD continuum. a Schematic illustration of the clustering coefficient. The purple node has a high clustering coefficient when compared to the blue node as it has a higher number of triangles around it. The black connections do not contribute to the calculation as they are not part of a closed triangle. b–f The AUC values of clustering coefficient for all groups at delays 1–5 respectively, calculated in the density range 5–50%. g Schematic illustration of global efficiency. The purple nodes have larger global efficiency when compared to blue nodes as they are more directly connected or through shorter paths. h–l The AUC values of global efficiency (density range: 5–50%) at temporal delays 1–5. In all plots, the boxplots denote the 25th and 75th percentiles of the data, while the whiskers extend to the largest and smallest data points. * Indicates a statistically significant result at p < 0.05. ** Indicates a statistically significant result at p < 0.001. All results were corrected for multiple comparisons using FDR