Table 4 Cox proportional-hazards models investigating the association between eGFRcr-cys and incident all-cause dementia by genetic risk for dementia

Dementia non-APOE PRS

 Low

   ≥ 90

184/10,607

1 (Reference)

1 (Reference)

  60–89

491/21,127

1.11 (0.94–1.32)

1.07 (0.90–1.27)

   < 60

58/1,521

1.72 (1.28–2.31)

1.43 (1.06–1.92)

 Intermediate

   ≥ 90

762/31,517

1 (Reference)

1 (Reference)

  60–89

1,846/63,585

1.01 (0.92–1.10)

1.00 (0.92–1.09)

   < 60

259/4,663

1.80 (1.56–2.08)

1.58 (1.37–1.83)

 High

   ≥ 90

341/10,641

1 (Reference)

1 (Reference)

  60–89

877/21,087

1.07 (0.95–1.22)

1.08 (0.95–1.23)

   < 60

95/1,526

1.60 (1.27–2.01)

1.39 (1.10–1.74)

APOE allele

 ε3/ε3

   ≥ 90

595/37,092

1 (Reference)

1 (Reference)

  60–89

1,494/75,296

1.02 (0.93–1.13)

1.00 (0.90–1.10)

   < 60

211/5,657

1.81 (1.54–2.12)

1.50 (1.28–1.76)

 ε4/ε4 or ε3/ε4

   ≥ 90

874/16,962

1 (Reference)

1 (Reference)

  60–89

1,990/32,298

1.01 (0.93–1.09)

0.98 (0.91–1.07)

   < 60

215/2,227

1.53 (1.32–1.78)

1.27 (1.09–1.48)

 ε2/ε2 or ε3/ε2

   ≥ 90

83/7,721

1 (Reference)

1 (Reference)

  60–89

288/16,984

1.32 (1.03–1.68)

1.28 (1.00–1.64)

   < 60

49/1,306

2.71 (1.90–3.86)

2.25 (1.58–3.20)