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Table 2 Cox proportional-hazards models investigating the association between eGFRcr-cys status and incident all-cause dementia by different follow-up periods

From: Kidney function, albuminuria, and their modification by genetic factors and risk of incident dementia in UK Biobank

  

Age and sex adjusted

Fully adjusteda

Follow-up period

Cases/Population

HR (95% CI)

HR (95% CI)

Complete follow-up

  ≥ 90

1,618/64,082

1 (Reference)

1 (Reference)

 60–89

3,932/129,095

1.01 (0.95–1.07)

1.00 (0.94–1.06)

  < 60

492/9,525

1.62 (1.46–1.79)

1.42 (1.28–1.58)

 ≤ 5 years

  ≥ 90

149/64,085

1 (Reference)

1 (Reference)

 60–89

361/129,095

0.97 (0.80–1.18)

0.98 (0.80–1.19)

  < 60

51/9,525

1.59 (1.15–2.20)

1.36 (0.98–1.90)

 > 5 to 10 years

  ≥ 90

717/62,661

1 (Reference)

1 (Reference)

 60–89

1,731/125,140

0.99 (0.91–1.08)

1.00 (0.91–1.09)

  < 60

240/8,792

1.71 (1.48–1.99)

1.53 (1.31–1.78)

 > 10 years

  ≥ 90

752/58,436

1 (Reference)

1 (Reference)

 60–89

1,840/114,968

1.03 (0.94–1.12)

1.01 (0.93–1.11)

  < 60

201/7,382

1.52 (1.30–1.78)

1.33 (1.13–1.56)

  1. Abbreviations: CI Confidence Interval, eGFRcr-cys Estimated Glomerular Filtration Rate Creatinine-Cystatin C Equation, HR Hazard Ratio
  2. aModels adjusted for age, sex, ethnicity, Townsend deprivation index, education, household income, country, smoking status, alcohol intake, body mass index, hypertension, diabetes, and APOE status