Table 1 Baseline characteristics of 202,716 participants by eGFRcr-cys status
eGFRcr-cys ml per min per 1.732 | |||
|---|---|---|---|
Characteristic |  < 60 N = 9,525 | 60–89 N = 129,095 |  ≥ 90 N = 64,082 |
Age in years, mean (SD) | 65.4 (2.8) | 64.4 (2.9) | 63.4 (2.7) |
Women, N (%) | 5,041 (52.9) | 67,640 (52.4) | 33,994 (53.1) |
Ethnicity, N (%) | |||
  White | 9,085 (95.9) | 124,852 (97.2) | 61,980 (97.1) |
  Non-white | 387 (4.1) | 3,626 (2.8) | 1,835 (2.9) |
Townsend deprivation index, quintiles, N (%) | |||
 1 (least deprived) | 1,470 (15.4) | 25,386 (19.7) | 13,736 (21.5) |
 2 | 1,638 (17.2) | 25,635 (19.9) | 13,166 (20.6) |
 3 | 1,778 (18.7) | 25,778 (20.0) | 12,938 (20.2) |
 4 | 1,937 (20.3) | 26,009 (20.2) | 12,556 (19.6) |
 5 (most deprived) | 2,698 (28.3) | 26,177 (20.3) | 11,631 (18.2) |
Education, N (%) | |||
 Primary | 3,690 (39.5) | 36,356 (28.6) | 14,247 (22.5) |
 Secondary | 3,422 (36.6) | 55,577 (43.7) | 30,297 (47.8) |
 Post-secondary non-tertiary | 909 (9.7) | 13,733 (10.8) | 7,137 (11.3) |
 Tertiary | 1,333 (14.3) | 21,545 (16.9) | 11,696 (18.5) |
Household income in GBP, N (%) | |||
  < 18,000 | 3,642 (49.3) | 37,259 (35.8) | 15,005 (28.4) |
 18,000–30,999 | 2,288 (31.0) | 34,104 (32.7) | 17,276 (32.7) |
 31,000–51,999 | 1,011 (13.7) | 20,792 (20.0) | 12,485 (23.6) |
 52,000–100,000 | 382 (5.2) | 9,780 (9.4) | 6,450 (12.2) |
  > 100,000 | 63 (0.9) | 2,244 (2.2) | 1,631 (3.1) |
Country, N (%) | |||
 England | 8,426 (88.5) | 115,219 (89.3) | 57,084 (89.1) |
 Scotland | 683 (7.2) | 8,732 (6.8) | 4,547 (7.1) |
 Wales | 416 (4.4) | 5,144 (4.0) | 2,451 (3.8) |
Smoking status, N (%) | |||
 Never | 4,152 (44.0) | 63,886 (49.8) | 32,640 (51.2) |
 Former | 4,204 (44.5) | 53,127 (41.4) | 26,913 (42.2) |
 Current | 1,084 (11.5) | 11,273 (8.8) | 4,198 (6.6) |
 Weekly alcohol intake in units, mean (SD) | 7.8 (11.0) | 10.7 (11.8) | 13.0 (12.5) |
BMI, N (%) | |||
 Underweight | 26 (0.3) | 406 (0.3) | 438 (0.7) |
 Normal | 1,440 (15.2) | 32,552 (25.3) | 25,428 (39.8) |
 Overweight | 3,663 (38.7) | 59,684 (46.4) | 27,982 (43.8) |
 Obese | 4,330 (45.8) | 35,964 (28.0) | 9,991 (15.7) |
Diabetes, N (%) | |||
 No | 7,769 (81.6) | 120,546 (93.38) | 59.846 (93.39) |
 Yes | 1,756 (18.4) | 8,549 (6.6) | 4,236 (6.6) |
Hypertension, N (%) | |||
 No | 1,100 (11.9) | 26,334 (22.1) | 14,900 (25.9) |
 Yes | 8,166 (88.1) | 92,664 (77.9) | 42,706 (74.1) |
Physical activity | |||
  Low (≦1200 MET minutes per week) | 3,208 (45.8) | 35,462 (35.1) | 16,199 (31.4) |
  High (> 1200 MET minutes per week) | 3,804 (54.3) | 65,658 (64.9) | 35,379 (68.6) |
APOE alleles, N (%) | |||
 ε3/ε3 | 5,657 (61.2) | 75,296 (60.4) | 37,092 (60.0) |
 ε4/ε4 or ε3/ε4 | 2,227 (24.2) | 32,298 (25.9) | 16,962 (27.5) |
 ε2/ε2 or ε3/ε2 | 1,306 (14.2) | 16,984 (13.6) | 7,721 (12.5) |
Non-APOE dementia PRS, N (%) | |||
 Low | 1,521 (19.7) | 21,127 (20.0) | 10,607 (20.1) |
 Intermediate | 4,663 (60.5) | 63,585 (60.1) | 31,517 (59.7) |
 High | 1,526 (19.8) | 21,087 (19.9) | 10,641 (20.2) |