| sCAA (n = 61) | Controls (n = 42) | P-value/adjusted p-value | B (95% CI)* |
---|
Age (years) | 72 ± 6 | 72 ± 6 | 0.94a | – |
Sex, F/M (n) | 27/34 | 21/21 | 0.56b | – |
MOCA | 26 [23–27]; n = 26 | N.A. | – | – |
Plasma |
Aβ38 (pg/ml) | 19.5 [15.8–22.8] | 17.1 [13.2–20.6] | 0.077a/0.092§ | 1.92 (-0.32–4.17) |
Aβ40 (pg/ml) | 169 [153–195] | 155 [137–192] | 0.14a/0.64§ | 3.97 (− 12.71–20.64) |
Aβ42 (pg/ml) | 31.9 ± 8.13 | 32.1 ± 6.03 | 0.74a/0.68§ | 0.58 (− 2.16–3.33) |
CSF |
Aβ38 (pg/ml) | 2174 ± 850; n = 16 | N.A. | – | – |
Aβ40 (ng/ml) | 6.36 ± 2.92; n = 30 | N.A | – | – |
Aβ42 (pg/ml) | 336 [165–400]; n = 30 | N.A | – | – |
- Values are medians and [IQR] except for age; plasma Aβ42, CSF Aβ38, and Aβ40 (mean ± SD,) and sex (n)
- Abbreviations: 95% CI 95% confidence interval, Aβ amyloid beta, B unstandardized beta coefficient, sCAA sporadic cerebral amyloid angiopathy, F female, IQR interquartile range, M male, MOCA Montreal Cognitive Assessment, N.A. not available, SD standard deviation
- aMann-Whitney test
- bChi-square test
- §p-value adjusted for age and sex
- *Unstandardized B coefficient from linear regression with plasma Aβ as a dependent variable, and age, sex, and group (patients with sCAA versus controls) as independent variables, with controls as the reference category