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Table 3 Characteristics and results of plasma and CSF analysis of sCAA patients and controls

From: Plasma amyloid beta 42 is a biomarker for patients with hereditary, but not sporadic, cerebral amyloid angiopathy

 

sCAA (n = 61)

Controls (n = 42)

P-value/adjusted p-value

B (95% CI)*

Age (years)

72 ± 6

72 ± 6

0.94a

Sex, F/M (n)

27/34

21/21

0.56b

MOCA

26 [23–27]; n = 26

N.A.

Plasma

Aβ38 (pg/ml)

19.5 [15.8–22.8]

17.1 [13.2–20.6]

0.077a/0.092§

1.92 (-0.32–4.17)

Aβ40 (pg/ml)

169 [153–195]

155 [137–192]

0.14a/0.64§

3.97 (− 12.71–20.64)

Aβ42 (pg/ml)

31.9 ± 8.13

32.1 ± 6.03

0.74a/0.68§

0.58 (− 2.16–3.33)

CSF

Aβ38 (pg/ml)

2174 ± 850; n = 16

N.A.

Aβ40 (ng/ml)

6.36 ± 2.92; n = 30

N.A

Aβ42 (pg/ml)

336 [165–400]; n = 30

N.A

  1. Values are medians and [IQR] except for age; plasma Aβ42, CSF Aβ38, and Aβ40 (mean ± SD,) and sex (n)
  2. Abbreviations: 95% CI 95% confidence interval, amyloid beta, B unstandardized beta coefficient, sCAA sporadic cerebral amyloid angiopathy, F female, IQR interquartile range, M male, MOCA Montreal Cognitive Assessment, N.A. not available, SD standard deviation
  3. aMann-Whitney test
  4. bChi-square test
  5. §p-value adjusted for age and sex
  6. *Unstandardized B coefficient from linear regression with plasma Aβ as a dependent variable, and age, sex, and group (patients with sCAA versus controls) as independent variables, with controls as the reference category