Table 1 Characteristics and results of plasma and CSF analysis of discovery D-CAA and control group

Age (years)

35 [24–47]

37 [34–45]

55 [51–60]

58 [53–63]

0.61^a

–

0.079^a

–

 < 0.001^a

–

Sex, F/M (n)

8/3

11/5

11/13

10/14

0.82^b

–

0.78^b

–

0.14^b

–

MMSE

30 [30–30]

29 [29, 30]

29 [27–30]; n = 23

29 [29, 30]

0.58^a

–

0.03^a

–

0.005^a

–

Plasma

 Aβ38 (pg/ml)

12.3 [10.3–13.0]

17.2 [13.9–18.9]

12.1 [10.1–13.8]

16.1 [14.1–19.9]

 < 0.001^a/ < 0.001^§

 − 5.22 (− 7.81 to − 2.63)

 < 0.001^a/ < 0.001^§

 − 4.81 (− 7.04 to − 2.58)

0.96^a/0.17^§

0.55 (− 2.36 to 3.46)

 Aβ40 (pg/ml)

132 ± 37

164 ± 28

132 ± 30

156 ± 27

0.019^c/0.009^§

 − 35.56 (− 61.15 to − 9.97)

0.005^c/0.01^§

 − 22.96 (− 40.31 to − 5.61)

0.98^c/0.70^§

 − 0.35 (− 24.18 to 23.48)

 Aβ42 (pg/ml)

20 ± 7

28 ± 4

21 ± 4

27 ± 5

 < 0.001^c/ < 0.001^§

 − 8.96 (− 13.11 to − 4.82)

0.001^c/ < 0.001^§

 − 5.38 (− 8.13 to − 2.64)

0.38^c/0.07^§

1.70 (− 2.17 to 5.56)

CSF

 Aβ40 (ng/ml)

3.17 [2.78–3.75]; n = 4

3.72 [3.33–4.68]; n = 5

1.36 [1.25–1.54]; n = 9

4.49 [1.41–5.23]^†; n = 3

0.29^a

–

0.036^a

–

0.003^a

–

 Aβ42 (pg/ml)

512 [414–601]; n = 4

1008 [847–1120]; n = 5

298 [251–357]; n = 9

1022 [785–1342]^†; n = 3

0.016^a

–

0.009^a–

–

0.006^a

–