Table 2 Top unique differentially expressed genes stratified for APOE4 or amyloid positivity status at follow-up compared to baseline

Up

COX6C

1.68

3.6 × 10⁻⁸

ENSG00000173867

2.12

1.5 × 10⁻²

RPS27

1.55

9.7 × 10⁻⁸

ZNF208

1.15

6.0 × 10⁻⁴

TOMM5

1.54

2.6 × 10⁻³

-

-

-

COX7B

1.53

1.5 × 10⁻⁷

-

-

-

RPS17

1.47

7.0 × 10⁻⁸

-

-

-

Down

LY75-CD302

− 5.60

1.8 × 10⁻¹⁰

ENSG00000241489

− 3.83

4.0 × 10⁻⁴

ENSG00000268614

− 1.65

3.8 × 10⁻³

SHISA7

− 1.51

7.6 × 10⁻⁴

YPEL4

− 1.62

3.4 × 10⁻⁶

WASF3

− 1.34

2.3 × 10⁻³

SHISA4

− 1.53

6.4 × 10⁻⁷

RNF208

− 1.33

5.6 × 10⁻⁴

SMIM24

− 1.52

9.1 × 10⁻⁷

PDGFA

− 1.14

5.3 × 10⁻⁴

Amyloid negative–positive or positive-positive

Amyloid negative-negative

Up

RPL17-C18orf32

3.85

0.01

FAU

1.14

0.04

EEF1A1

2.17

0.03

RPS9

1.00

0.05

RPL14

1.43

0.02

-

-

-

RPS11

1.34

0.01

-

-

-

B2M

1.30

0.04

-

-

-

Down

SELENBP1

− 2.88

0.04

NRGN

− 2.44

0.03

PDZK1IP1

− 2.75

0.04

BCL2L1

− 2.28

0.03

GRINA

− 2.07

0.05

ALAS2

− 2.20

0.05

NCF1

− 1.72

0.05

DMTN

− 2.14

0.04

AKT2

− 1.60

0.02

PSMF1

− 2.07

0.03