Table 1 Characteristics of F-PACK participants stratified for APOE4 status. Data are reported as median and range (minimum to maximum) for continuous variables, and numerical for categorical variables. N = 65: ε2ε3 N = 5; ε2ε4 N = 1; ε3ε3 N = 29; ε3ε4 N = 28; ε4ε4 N = 2
|  | APOE4 non-carrier (N = 34) | APOE4 carrier (N = 31) | Statistics |
|---|---|---|---|
Sex (male/female) | 17/17 | 18/13 | Χ2 = 0.16, p = 0.69 |
BDNF 66 met carriers (N) | 18 | 16 | Χ2 = 0, p = 1 |
Age (years) | 68 (56–80) | 69 (56–80) | T =  − 0.42, p = 0.68 |
Education (years) | 14 (8–20) | 16 (9–23.5) | T = 2.17, p = 0.03 |
MMSE | 29.5 (27–30) | 30 (28–30) | W = 555.5, p = 0.68 |
CDR | 0 | 0 | NA |
AVLT TL (/75) | 46 (31–68) | 46 (35–68) | T = 0.32, p = 0.75 |
AVLT %DR | 82.6 (30–107.7) | 84.6 (58.3–107.7) | W = 550, p = 0.77 |
BSRT TR (/12) | 7.7 (5.6–10.8) | 7.8 (4.9–10.3) | T =  − 0.74, p = 0.46 |
BSRT DR (/12) | 8 (2–12) | 8 (3–12) | W = 481.5, p = 0.55 |
BNT (/60) | 57 (46–60) | 57 (41–60) | W = 530, p = 0.97 |
AVF (# words) | 24 (16–33) | 24 (18–38) | T = 0.78, p = 0.44 |
LVF (# words) | 35 (14–65) | 38 (9–61) | T = 0.72, p = 0.47 |
PALPA49 (/30) | 28 (20–30) | 27 (23–29) | W = 468, p = 0.43 |
RPM (/60) | 45 (22–57) | 45 (22–57) | W = 515.5, p = 0.88 |
TMT B/A | 2.3 (1.3–4.8) | 2.4 (1.0–4.8) | T =  − 0.22, p = 0.83 |
Baseline Centiloid | 4.6 (− 13.1–99.8) | 7.7 (− 14.8–116.8) | W = 620, p = 0.23 |
Baseline amyloid positivity (N) | 3 (8.8%) | 4 (12.9%) | Χ2 = 0.02, p = 0.90 |
Follow-up Centiloid | 3.1 (− 16.8–126.9) | 7.9 (− 13.4–182.8) | W = 666, p = 0.07 |
Follow-up amyloid positivity (N) | 3 (8.8%) | 6 (19.4%) | Χ2 = 0.75, p = 0.39 |
Time interval (years) | 5.7 (4.4–8.6) | 4.5 (3.4–7.2) | W = 272, p = 0.0008 |
Amyloid rate of change |  − 0.15 (− 2.8–4.1) | 0.86 (− 2.6–13.8) | W = 672, p = 0.06 |
Amyloid accumulators (N) | 5 (14.7%) | 7 (22.6%) | Χ2 = 0.25, p = 0.62 |