The identification and cognitive correlation of perfusion patterns measured with arterial spin labeling MRI in Alzheimer’s disease

Table 5 Correlation between subject expression scores of ADRP, global CBF and relative CBF of VOI, and cognitive function in patients with AD

	ADRP subject score				CBF
	Identification cohort		Validation cohort		Global		Right precuneus		Left posterior cingulate		Left angular		Right inferior parietal lobule		Right inferior temporal gyrus
	r	P	r	P	r	P	r	P	r	P	r	P	r	P	r	P
Global cognition	− 0.637	< 0.001	− 0.441	0.035	0.239	0.213	0.434	0.019	0.619	< 0.001	0.537	0.003	0.475	0.009	0.361	0.054
Memory	− 0.430	0.020	0.055	0.805	0.218	0.256	0.503	0.005	0.470	0.010	0.438	0.018	0.435	0.018	0.426	0.021
Processing speed	− 0.716	< 0.001	− 0.599	0.003	0.246	0.198	0.502	0.006	0.645	< 0.001	0.602	< 0.001	0.498	0.006	0.483	0.008
Executive function	− 0.674	< 0.001	− 0.559	0.006	0.237	0.215	0.436	0.018	0.577	0.001	0.522	0.004	0.563	0.002	0.530	0.003
Language	− 0.464	0.011	− 0.270	0.213	0.352	0.061	0.230	0.231	0.434	0.019	0.506	0.005	0.312	0.099	0.293	0.123
Visuospatial function	− 0.696	< 0.001	− 0.478	0.021	0.232	0.227	0.338	0.073	0.573	0.001	0.488	0.007	0.708	< 0.001	0.589	< 0.001

z-scores for global cognition and different cognitive domains were calculated from raw scores of neuropsychological assessments referenced the mean and standard deviation of all NCs. Global cognition was measured with the MMSE. Memory = average of total learning, delayed recall and recognition on the AVLT and the BVMT-R; processing speed = average of the SDMT and the TMT-A; executive function = average of the TMT-B and the Stroop color-word test; language = average of the AFT, the COWAT and the BNT; visuospatial function = the JLO. Data for cognitive domains was missing from 3 AD patients of identification cohort. Correlation analysis for global and regional CBF were conducted in AD patients from identification cohort

ISSN: 1758-9193