Skip to main content

Table 4 Estimated rate of atrophy change as a function of baseline tau-PET patterns (discrete scale)

From: Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity

Fixed effects

Entorhinal cortex

Neocortex

Estimate (SE)

Estimate (SE)

Intercept

4.25 (0.23) **

2.68 (0.07) **

Age

−0.01 (0.003) **

−0.003 (0.001) *

TR

−0.004 (0.02)

−0.009 (0.01)

TP

−0.01 (0.02)

0.004 (0.01)

TADB

−0.4 (0.06) **

−0.08 (0.02) **

LPB

−0.18 (0.08) *

−0.04 (0.02)

CPB

0.01 (0.07)

−0.02 (0.02)

TADB × TR

0.1 (0.03) **

0.03 (0.01) *

TADB × TP

−0.08 (0.03) *

−0.01 (0.01)

LPB × TR

0.1 (0.04) *

0.01 (0.02)

LPB × TP

−0.09 (0.04) *

−0.002 (0.01)

CPB × TR

0.02 (0.03)

0.01 (0.01)

CPB × TP

0.001 (0.03)

0.002 (0.01)

  1. Changes in atrophy (thickness) are estimated by the linear mixed effects model with individual-specific intercepts. The linear mixed effects model was centered at TB and minimal tau pattern. Longitudinal atrophy was modeled as the dependent variable. Age, time, tau-PET pattern at baseline (TADB, LPB, CPB), and interactions of the patterns with time were modeled as fixed effects. The significant effects corresponding to p≤0.001 and p≤0.05 are marked by ** and * respectively. SE standard error in coefficient; TR retrospective timepoint; TP prospective timepoint, TADB typical AD pattern at baseline, LPB limbic predominant pattern at baseline, CPB cortical predominant pattern at baseline
Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193