Fig. 3
From: A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism
RNA-sequencing analysis shows pathways effected by CAD-31. A heat map of significant genes in hippocampal tissue between the control (C), CAD-31-treated control (C + 31), APPswe/PS1∆E9 mice (Alzheimer’s disease [AD]), and CAD-31-treated APPswe/PS1∆E9 mice (AD + 31) shows three distinct gene expression profiles. a Pathway analysis demonstrated that CAD-31 modulates neuroactive ligand-receptor interaction pathways in both the control and AD mice (drug effect and drug-model effect). The gene grouping generated by that AD model showed effects on proinflammatory pathways. b Advanced statistical analysis produced 29 genes differentially expressed between the control and CAD-31-treated control mice, as well as a 730-gene difference between the AD and CAD-31-treated AD mice. Pathway analysis revealed prosynaptic, metabolic, and disease-related pathways being changed by CAD-31 treatment. n = 3 per group. AMPK Adenosine monophosphate-activated protein kinase, KEGG Kyoto Encyclopedia of Genes and Genomes, TNF Tumor necrosis factor