Interaction term | CSF cystathionine | CSF SAH | CSF 5-MTHF | Plasma Hcy |
---|
CSF p-tau181 |
Age | −0.0011 | −0.0098 | 0.0036 | 0.0113 |
Sexa
| −0.0652 | −0.4815b
| 0.3443 | −0.6850b
|
APOE ε4 genotypec
| 0.2169 | 0.5126b
| −0.5687b
| 1.1427d
|
CDR categorye
| 0.1877 | 0.2122 | −0.2434 | 0.2833 |
CSF tau |
Age | | −0.0076 | 0.0099 | |
Sexa
| | −0.7407f
| 0.4541 | |
APOE ε4 genotypec
| | 0.4953 | −0.6965 | |
CDR categorye
| | 0.1352 | −0.2681 | |
-
Abbreviations: APOE Apolipoprotein E, CDR Clinical Dementia Rating, CSF Cerebrospinal fluid, Hcy Homocysteine, 5-MTHF 5-Methyltetrahydrofolate, p-tau181 Tau phosphorylated at threonine 181, SAH S-adenosyl-L-homocysteine
- Every interaction was tested in separate models, with only one interaction per model. Values of the regression interaction terms are reported, and their difference from 0 was assessed with an F test in analysis of variance
-
aFemales (versus reference males)
-
b
p ≤ 0.05
-
c
APOE ε4 carriers (versus reference noncarriers)
-
d
p ≤ 0.001
-
eCDR >0 (versus reference CDR 0)
-
f
p ≤ 0.01