Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer’s disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database

Table 6 Results of the stepwise linear regression investigating the association of baseline demographics, cognitive scores, cerebrospinal fluid markers and positron emission tomography data, with prognosis in terms of final status, cognitive score evolution and time to conversion in the longitudinal cohort

Association with	Last known status (NL, MCI, AD)		MMS annual change		CDR annual change		ADAS-cog annual change		Time to conversion
	r ²	p Value	r ²	p Value	r ²	p Value	r ²	p Value	r ²	p Value
Sex		ns		ns		ns		ns		ns
Age		ns		ns		ns		ns		ns
ApoE4		ns		ns		ns		ns		ns
Baseline cognition
GDS		ns		ns	0.02	0.04		ns		ns
MMSE		ns	0.10	<10⁻⁸		ns	0.10	<0.001		ns
CDR	0.38	<10⁻¹⁶		ns	0.08	<10⁻⁸		ns		ns
ADAS-cog	0.18	<10⁻¹⁵	0.18	<10⁻¹⁸	0.14	<10⁻¹⁶		ns	0.10	0.03
Baseline CSF
Aβ_1–42		ns		ns		ns		ns		ns
Tau		ns	0.03	0.02		ns		ns		ns
p-Tau₁₈₁	0.03	0.02		ns		ns		ns		ns
p-Tau/Aβ		ns		ns		ns		ns		ns
Baseline PET
SUVr (pons)	0.05	<0.001^a		ns	0.06	<10^−5a	0.08	0.001^a		ns
SUVr (crb)	0.03	0.02		ns		ns		ns		ns
SUVr (comp)	0.05	<0.001		ns	0.05	<10⁻⁵	0.07	0.005		ns

Abbreviations: Aβ Amyloid-β_1–42, AD Alzheimer’s disease, ADAS-cog Alzheimer’s Disease Assessment Scale–Cognitive Subscale, ApoE Apolipoprotein E, CDR Clinical Dementia Rating, Comp Composite, Crb Cerebellar, CSF Cerebrospinal fluid, GDS Geriatric Depression Scale, MCI Mild cognitive impairment, MMSE Mini Mental State Examination, NL Normal, PET Positron emission tomography, Pons Pontine, p-tau Phosphorylated tau, SUVr Standardised uptake value ratio, ns Not significant
All p values are corrected for multiple comparisons
^aRemained an independent predictor when evaluated jointly

ISSN: 1758-9193