Fig. 3From: Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampusMelatonin reduced astrogliosis in soluble Aβ1–42-injected rats. a Representative images of immunofluorescent staining for GFAP in the dentate gyrus (DG) of the hippocampus. b Representative images of immunofluorescent staining for GFAP in the CA1 region of the hippocampus. c Representative images of immunofluorescent staining for GFAP in the CA3 region of the hippocampus. d Statistical analysis of immunofluorescent staining for GFAP in the DG and the CA1 and CA3 regions. e Representative western blot images for GFAP in the hippocampus. f Statistical analysis of the relative intensity of GFAP immunoreactive bands from hippocampal tissue samples. Scale bar = 100 μm. *p < 0.05 and **p < 0.01 compared with sham-operated rats; # p < 0.05 and ## p < 0.01 compared with Aβ1–42-injected rats; ^ p < 0.05 compared with melatonin-injected rats. DAPI 4′,6-diamidino-2-phenylindole, GFAP glial fibrillary acidic protein, Ctrl control group, Aβ Aβ1–42-injected group, Mel melatonin-injected group, Aβ + Mel dual Aβ1–42 and melatonin-injected groupBack to article page