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Table 1 In vivo distribution of I-125–labeled drugs measured in blood, heart, brain, and injection regions

From: Central delivery of iodine-125–labeled cetuximab, etanercept and anakinra after perispinal injection in rats: possible implications for treating Alzheimer’s disease

 

Blood AC, %ID/g

Heart AC, %ID/g

Brain AC, %ID/g

Perispinal region AC, %ID/g

Dorsal tail vein AC, %ID/g

Cetuximab

     

  Perispinal

     

   Rat 1

2.06

0.39

4.05

0.06

–

   Rat 2

0.19

0.05

0.01

17.15

–

  Dorsal tail vein

     

   Rat 3

5.24

1.61

0.10

–

0.46

Etanercept

     

  Perispinal

     

   Rat 4

0.14

0.04

0.01

1.10

–

   Rat 5

0.10

 0.03

0.01

0.93

–

  Dorsal tail vein

     

   Rat 6

2.98

0.91

0.08

–

0.20

Anakinra

     

  Perispinal

     

   Rat 7

0.30

0.11

0.06

10.86

–

   Rat 8

0.16

0.07

0.02

7.31

–

  Dorsal tail vein

     

   Rat 9

0.37

0.19

0.04

–

0.15

  1. Abbreviations: AC average concentration, %ID/g percentage injected dose per gram of tissue
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Alzheimer's Research & Therapy

ISSN: 1758-9193