From: Clinical and imaging features of mixed Alzheimer and vascular pathologies
Study | N | AD = | VCI/VBI | VBI and AD correlations |
---|---|---|---|---|
ADNI [50] | N = 819 | NINDS-ADRDA | VRFs | VRFs were not associated with AD biomarkers |
229 NCI | Â | WMH | Increased time-varying WMHs were associated with faster decline in executive function and lower FDG uptake in NCI | |
397 CI | ||||
193Â AD | ||||
Amsterdam Dementia Cohort [49] | N = 914 | NINDS-ADRDA | VCI by NINDS-AIREN criteria | The presence of both MBs and WMHs was associated with lower CSF levels of Aβ42, indicating a direct relationship between SVD and AD pathology (note: could SVD be CAA?) |
337 NCI | ||||
547Â AD | ||||
30 VCI | The presence of lacunes was associated with higher Aβ42 in vascular dementia (standardized beta = 0.17, P = 0.07) and lower tau in AD (standardized beta = -0.07, P = 0.05) but there were no effects for Aβ42 or phosphorylated tau181 in AD (note: could SVD with lacunes be arteriolosclerosis?) |