Changes in the neurochemistry of athletes with repetitive brain trauma: preliminary results using localized correlated spectroscopy

Table 4 Additional metabolites of interest

Molecule	Coupling	F2–F1 (ppm)	Control mean volume/Cr	RBT mean volume/Cr	% Diff between mean and RBT	Effect size
NAA	-CH3	2.00–2.00	1.215 ± 0.101	1.294 ± 0.070	7 ± 10	0.95
tCho	(CH3)3-N + −CH2-CH2-OH	3.51-4.05	0.018 ± 0.002	0.020 ± 0.016	11 ± 81	0.23
	(CH3)3-N + −CH2-CH2-OH	3.20-3.20	0.726 ± 0.009	0.774 ± 0.052	7 ± 7	1.63
mI	-CH(OH)-CH(OH)	3.63–3.29	0.029 ± 0.013	0.032 ± 0.011	10 ± 61	0.26
		3.55–3.55	0.342 ± 0.013	0.354 ± 0.029	4 ± 10	0.58

Data are presented as described in Table 3, that is, relative to creatine. In all cases, the differences between control and RBT were not statistically significant.
Abbreviations: mI, myo-inositol; NAA, N-acetyl aspartate; RBT, repetitive brain trauma; tCho, total choline. In bold are the proton groups that give rise to the crosspeak chemical shifts indicated in the third column.

ISSN: 1758-9193