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Figure 3 | Alzheimer's Research & Therapy

Figure 3

From: Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography

Figure 3

Neuropathology of patient 13. A. Angular gyrus immunostained against beta-amyloid (4G8). Arrows indicate neuritic plaques and arrowhead indicates cerebral amyloid angiopathy, a typical finding in Alzheimer’s disease patients (Scale bar: 250 μm); B. Inferior temporal gyrus immunostained against phospho-tau (CP-13). The arrows point to neurofibrillary tangles, characteristic of AD. Note their flame-like shape (Scale bar: 500 μm); C. Precentral gyrus immunostained against phospho-tau (CP-13). Arrows indicate ballooned neurons in the cortical deep layers, commonly seen in CBD (Scale bar: 500 μm); D. Precentral gyrus immunostained against phospho-tau (CP-13). The line divides the cortex to the right (cx) and the white matter to the left (WM). Note the striking positivity of white matter for phospho-tau, a feature seen in CBD but not in other tauopathies or AD. AD, Alzheimer’s disease; CBD, corticobasal degradation.

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Alzheimer's Research & Therapy

ISSN: 1758-9193