Differentiating between visual hallucination-free dementia with Lewy bodies and corticobasal syndrome on the basis of neuropsychology and perfusion single-photon emission computed tomography

Table 6 Areas of relative hypoperfusion on SPECT when VHF-DLB is compared to their respective control group

Anatomical locus (Brodmann area)	Talairach coordinates			Number of voxels	SPM t-score (P-value)
Anatomical locus (Brodmann area)	x	y	z
VHF-DLB versus controls (FWE-corr)
Left middle temporal gyrus (21)	−57	−49	−3	413	6.2 (P =0.000)
Right middle temporal gyrus (39)	44	−63	31	1292	5.9 (P =0.001)
Right superior parietal lobule (7)	30	−64	46		5.6 (P =0.003)
Left precuneus (19)	−34	−64	42	1195	5.9 (P =0.001)
Left superior temporal gyrus (39)	−48	−57	27		5.7 (P =0.002)
Left inferior parietal lobule (40)	−46	−56	39		5.5 (P =0.004)
Right middle temporal gyrus (21)	61	−35	−10	211	5.4 (P =0.005)
Left middle occipital gyrus	−28	−89	−2	100	5.1 (P =0.013)
VHF-DLB versus controls (FDR-corr)
Left middle frontal gyrus (21)	−57	−49	−3	33550	6.2 (P =0.000)
Left precuneus (19)	−34	−64	42		5.9 (P =0.000)
Right middle temporal gyrus (39)	44	−63	31		5.9 (P = 0.000)
Right middle frontal gyrus (8)	36	16	45	1743	3.9 (P =0.002)
Right middle frontal gyrus (9)	36	27	37		3.9 (P =0.002)
Right superior frontal gyrus (8)	20	39	39		3.7 (P =0.003)
Left medial frontal gyrus (11)	−4	61	−15	144	3.7 (P =0.003)
Right inferior frontal gyrus (47)	50	27	−3	344	3.6 (P =0.004)
Left sub-lobar caudate	−14	10	5	41	3.4 (P =0.006)
Right superior frontal gyrus (9)	14	52	25	23	3.2 (P =0.008)

FDR-corr ,corrected for False Discovery Rate; FWE-corr, corrected for Family-Wise Error; SPECT, single-photon emission computed tomography; SPM, Statistical Parametric Mapping; VHF-DLB, visual hallucination-free dementia with Lewy bodies.

ISSN: 1758-9193