From: CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques
SP | Diffuse | Primitive | Classic | Burnt out | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Valid N | SP | OR (95% CI) | P-value | Diffuse | OR (95% CI) | P-value | Primitive | OR (95% CI) | P-value | Classic | OR (95% CI) | P-value | Burnt out | OR (95% CI) | P-value | |
APOEε4-1 | 388 | 88 (22.7) | - | - | 12 (3.1) | - | - | 19 (4.9) | - | - | 44 (11.3) | - | - | 13 (3.4) | - | - |
APOEε4+ | 174 | 74 (42.5) | 3.2 (2.05 to 4.90) | <0.0001* | 9 (5.2) | 2.4 (0.97 to 5.86) | 0.059 | 16 (9.2) | 2.8 (1.37 to 5.74) | 0.005* | 37 (21.3) | 3.2 (1.83 to 5.48) | <0.0001* | 12 (6.9) | 3.8 (1.56 to 9.01) | 0.003* |
CLU TT2 | 336 | 89 (26.5) | - | - | 13 (3.9) | - | - | 22 (6.5) | - | - | 48 (14.3) | - | - | 6 (1.8) | - | - |
CLU C+ | 194 | 60 (30.9) | 1.1 (0.73 to 1.76) | 0.570 | 6 (3.1) | 0.79 (0.29 to 2.14) | 0.641 | 11 (5.7) | 0.9 (0.39 to 1.84) | 0.680 | 27 (13.9) | 0.99 (0.56 to 1.77) | 0.988 | 16 (8.2) | 4.4 (1.61 to 12.2) | 0.004* |
CR1 AA2 | 186 | 56 (30.1) | - | - | 8 (4.3) | - | - | 9 (4.8) | - | - | 28 (15.1) | - | - | 11 (5.9) | - | - |
CR1 C+ | 361 | 102 (28.3) | 0.9 (0.62 to 1.54) | 0.924 | 12 (3.3) | 0.71 (0.28 to 1.80) | 0.475 | 24 (6.6) | 1.2 (0.55 to 2.77) | 0.611 | 53 (14.7) | 0.85 (0.48 to 1.49) | 0.572 | 13 (3.6) | 0.57 (0.24 to 1.40) | 0.221 |
PICALM CC2 | 219 | 71 (32.4) | - | - | 7 (3.2) | - | - | 19 (8.7) | - | - | 37 (16.9) | - | - | 8 (3.7) | - | - |
PICALM T+ | 327 | 87 (26.6) | 0.6 (0.41 to 0.95) | 0.028* | 12 (3.7) | 1.09 (0.42 to 2.84) | 0.864 | 16 (4.9) | 0.5 (0.26 to 1.09) | 0.086 | 42 (12.8) | 0.73 (0.42 to 1.25) | 0.253 | 17 (5.2) | 1.36 (0.55 to 3.39) | 0.508 |