Alzheimer's Research & Therapy

Table 1 Effect of statin therapy with simvastatin or atorvastatin on analytes in non-PSEN1 and PSEN1 subjects

From: Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4

	Primary objective		Drug effect				Controlled for lipids
	Statins		Atorvastatin		Simvastatin		Atorvastatin		Simvastatin
Analyte	% change	P -value	% change	P -value	% change	P -value	% change	P -value	% change	P -value
Non-PSEN1
sAPPα	7	0.013	-	NS	13.1	0.019	9.6	0.0082	23.7	0.0005
sAPPβ	-	NS	-	NS	-	NS	-	NS	-	NS
Phospho-tau	-	NS	-	NS	-	NS	-	NS	-	NS
Total tau	-	NS	-	NS	-	NS	-	NS	-	NS
AB42	-	NS	-	NS	-	NS	-	NS	-	NS
PSEN1
sAPPα	-16.5	0.0014	-	NS	-26.5	0.0002	-	NS	-24.1	0.0003
sAPPβ	-21.2	0.0005	-	NS	-31.5	0.0001	-	NS	-	NS
Phospho-tau	-8.3	0.076	-	NS	-	NS	-	NS	-	NS
Total tau	-	NS	-	NS	-	NS	-	NS	-	NS
AB42	-	NS	-	NS	-	NS	-	NS	-	NS

Aβ42 = amyloid-beta 42; NS, not significant; sAPP, soluble amyloid precursor protein.

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ISSN: 1758-9193

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