From: Cerebral microbleeds: overview and implications in cognitive impairment
1. Definite CAA | Full post-mortem examination demonstrating: |
• Lobar, cortical, or corticosubcortical hemorrhage | |
• Severe CAA with vasculopathya | |
• Absence of other diagnostic lesion | |
2. Probable CAA with supporting pathology | Clinical data and pathologic tissue (evacuated hematoma or cortical biopsy) demonstrating: |
• Lobar, cortical, or corticosubcortical hemorrhage | |
• Some degree of CAA in specimen | |
• Absence of other diagnostic lesion | |
3. Probable CAA | Clinical data and magnetic resonance imaging (MRI) or computed tomography (CT) demonstrating: |
• Multiple hemorrhages restricted to lobar, cortical, or corticosubcortical regions (cerebellar hemorrhage allowed) | |
• Age >55 years | |
• Absence of other cause of hemorrhageb | |
4. Possible CAA | Clinical data and MRI or CT demonstrating: |
• Single lobar, cortical, or corticosubcortical hemorrhage | |
• Age >55 years | |
• Absence of other cause of hemorrhageb |