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Figure 4 | Alzheimer's Research & Therapy

Figure 4

From: β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

Figure 4

Microhemorrhages are increased by hyperhomocysteinemia in both wild-type and APP/PS1 transgenic mice. (A) and (B) Prussian blue–positive microhemorrhages in the cerebral cortices of APP/PS1 mice fed the hyperhomocysteinemia (HHcy) diet. Both images were obtained at 200× original magnification with a neutral red background stain. Scale bar = 25 μm. (C) Mean number of microhemorrhages per section for wild-type (WT) and APP/PS1 transgenic mice fed the control (n = 16 for WT mice and n = 20 for APP/PS1 mice, black bars) and the HHcy diet (n = 16 for WT mice and n = 20 for APP/PS1 mice, white bars). **P < 0.01 compared to the control group for the given genotype. Error bars show SEM.

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Alzheimer's Research & Therapy

ISSN: 1758-9193