Genetics of Alzheimer disease in the pre- and post-GWAS era

Table 3 Late-onset Alzheimer disease genome-wide association study: estimated population attributable risks of the top variants.

			Non-ApoE hits (paper)			Non-ApoE hits (AlzGene meta-analysis)			ApoE-related hits
Reference	Best gene(s)	Best SNP(s)	MAF	OR	PAR	MAF	OR	PAR	Best gene(s)	Best SNP(s)	MAF	OR	PAR
Grupe et al. [50]	GALP	rs3745833	0.35	1.2	6.5%	0.35	1.13	4.4%	TOMM40	rs157581	0.15	2.73	20.6%
Coon et al. [51]	-	-	-	-	-	-	-	-	APOC1	rs4420638	0.18	4.01	35.1%
Reiman et al. [52]	GAB2	rs2373115	0.81	1.66	34.8%	0.82	1.22	15.3%	-	-	-	-	-
Li et al. [53]	GOLPH2	rs7019241	0.13	0.69	28.1%	-	-	-	APOC1	rs4420638	0.18	-	-
Abraham et al. [54]	LRAT	rs201825	0.45	1.3	11.9%	-	-	-	-	-	-	-	-
Bertram et al. [55]	chr14q31.2	rs11159647	0.48	1.4	16.0%	-	-	-	APOC1	rs4420638	0.18	-	-
Beecham et al. [56]	12q13	rs11610206	-	-	-	-	-	-	-	-	-	-	-
Feulner et al. [57]	LMNA	rs915179	0.35	-	-	-	-	-	TOMM40	rs157580 and rs2075650	0.4-0.14	-	-
Poduslo et al. [58]	TRPC4AP	rs6087664	-	-	-	-	-	-	-	-	-	-	-
Carrasquillo et al. [59]	PCDH11X	rs2573905	0.46	1.29	11.8%	-	-	-	TOMM40	rs2075650	0.13	3.29	22.9%
Harold et al. [60]	CLU	rs11136000	0.40	0.86	8.9%	0.6	0.85 (CLU)	9.6%	TOMM40	rs2075650	0.15	2.53	18.7%
	PICALM	rs3851179	0.37	0.86	9.3%	0.36	0.88 (PICALM)	8.0%
Lambert et al. [61]	CLU	rs11136000	0.38	0.86	9.2%	0.6	0.85 (CLU)	9.6%	-	-	-	-	-
	CR1	rs6656401	0.19	1.21	3.8%	0.18	1.19 (CR1)	3.3%

The minor allele frequencies (MAFs), odds ratios (ORs), and population attributable risks (PARs) of the best single-nucleotide polymorphisms (SNPs) in the top gene(s) from the 11 late-onset Alzheimer disease genome-wide association studies are shown, where available from the original publications. MAFs of the rs157581 and rs4420638 SNPs were not shown in the original publications and were obtained from the dbSNP database for subjects of European origin. The formula used to calculate PAR was F(OR - 1)/(F(OR - 1) + 1), where F = frequency of the risk allele and OR = odds ratio of the risk allele. Where available, the MAFs, ORs, and PARs emerging from meta-analyses in the AlzGene website are shown for the non-APOE results.

ISSN: 1758-9193