The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice

Table 1 Top up-regulated genes one-hour treatment J147

Gene symbol	Gene title	Entrez gene	Fold change: J147 (1 hr) vs Control
*Egr3*	early growth response 3	13655	8.0
*Ngf*	nerve growth factor	18049	2.8
*Spred2*	sprouty related, EVH1 domain containing 2	114716	2.7
	No title (chr8:13161324 to 13161817)		2.6
*Egr1*	early growth response 1	13653	2.5

DNA microarray was used to evaluate changes in gene expression following one hour of treatment of HT22 neuronal cells with 10 μM J147. The top five genes showing increases in mRNA expression are shown in this table with Egr3 and NGF being the top two of over 34,000 named mouse genes probed.

ISSN: 1758-9193