Figure 6

In vivo recording of field excitatory postsynaptic potentials (fEPSPs), from the stratum radiatum in response to stimulation of the Schaffer collateral/commissural pathway in wild type mice, injected with saline and D-Ala2 glucose-dependent insulinotropic polypeptide (GIP and in APP/PS1 mice. At 6 months, (A) potentiation of the fEPSP after high-frequency stimulation and (B) paired-pulse facilitation in area CA1. The inter-stimulus interval was set at 25 to 200 ms. Data represent mean ± standard error of the mean (SEM) of six mice per group (two-way repeated measures analysis of variance, ANOVA). In the APP/PS1 mice, (C) potentiation of the fEPSP after high-frequency stimulation and (D) paired-pulse facilitation in area CA1. The inter-stimulus interval was set at 25 to 200 ms. Data represent mean ± SEM of eight mice per group (two-way repeated measures ANOVA). At 12 months, (E) potentiation of the fEPSP after high frequency stimulation and (F) paired-pulse facilitation in area CA1. The inter-stimulus interval was set at 25 to 200 ms. Data represent mean ± SEM of seven mice per group (two-way repeated measures ANOVA). In the APP/PS1 mice, (G) potentiation of the fEPSP after high-frequency stimulation and (H) paired-pulse facilitation in area CA1. The inter-stimulus interval was set at 25 to 200 ms. Data represent mean ± SEM of seven mice for the saline group and six for the D-Ala²GIP group (two-way repeated measures ANOVA).