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Table 1 Pharmacokinetic properties of SPI-1865 in mouse and rat

From: Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

Species

Volume (L/kg)2

Brain/plasma (24 h)1

T1/2 (h)2

Tmax

Mouse

9.2

0.4 to 1.4

8.3

approximately 4 hrs

Rat

5.8

0.5 to 1.5

129

6 to 8 hrs

  1. The pharmacokinetic properties of SPI-1865 were assessed in both mouse and rat. 1Based on various oral dosing regimens; 2Volume and T1/2 values are based on intravenous drug delivery data. T1/2, half-life; Tmax, time of maximum concentration.
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Alzheimer's Research & Therapy

ISSN: 1758-9193