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  1. Frontotemporal dementia (FTD) is a common dementia syndrome in patients under the age of 65 years with many features overlapping with amyotrophic lateral sclerosis (ALS). The link between FTD and ALS has been ...

    Authors: Sharon J Sha and Adam Boxer

    Citation: Alzheimer's Research & Therapy 2012 4:46

    Content type: Review

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  2. Hexanucleotide expansion intronic to chromosome 9 open reading frame 72 (C9ORF72) has recently been identified as the most common genetic cause of both familial and sporadic amyotrophic lateral sclerosis and of f...

    Authors: Jennifer S Yokoyama and Howard J Rosen

    Citation: Alzheimer's Research & Therapy 2012 4:45

    Content type: Review

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  3. Curcumin is a polyphenolic compound derived from the plant Curcuma Long Lin that has been demonstrated to have antioxidant and anti-inflammatory effects as well as effects on reducing beta-amyloid aggregation. It...

    Authors: John M Ringman, Sally A Frautschy, Edmond Teng, Aynun N Begum, Jenny Bardens, Maryam Beigi, Karen H Gylys, Vladimir Badmaev, Dennis D Heath, Liana G Apostolova, Verna Porter, Zeba Vanek, Gad A Marshall, Gerhard Hellemann, Catherine Sugar, Donna L Masterman…

    Citation: Alzheimer's Research & Therapy 2012 4:43

    Content type: Research

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  4. Therapeutic products that depend on the use of an in vitro diagnostic biomarker test to confirm their effectiveness are increasingly being developed. Use of biomarkers is particularly meaningful in the context of...

    Authors: Hugo Vanderstichele, Erik Stoops, Eugeen Vanmechelen and Andreas Jeromin

    Citation: Alzheimer's Research & Therapy 2012 4:39

    Content type: Review

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  5. Earlier reports of chromosome 9p-linked frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) kindreds observed psychosis as a prominent feature in some patients. Since the discovery of chromo...

    Authors: Leonel T Takada and Sharon J Sha

    Citation: Alzheimer's Research & Therapy 2012 4:38

    Content type: Review

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  6. Mutation in chromosome 9 open reading frame 72 (C9orf72) is a major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), referred to as C9FTD/ALS. The function of the protein is...

    Authors: Tibor Hortobágyi

    Citation: Alzheimer's Research & Therapy 2012 4:37

    Content type: Commentary

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  7. Frontotemporal dementia (FTD) is a common cause of early-onset dementia with a significant genetic component, as underlined by the recent identification of repeat expansions in the gene C9ORF72 as a major cause o...

    Authors: Colin J Mahoney, Laura E Downey, Gerard R Ridgway, Jon Beck, Shona Clegg, Melanie Blair, Sarah Finnegan, Kelvin K Leung, Tom Yeatman, Hannah Golden, Simon Mead, Jonathan D Rohrer, Nick C Fox and Jason D Warren

    Citation: Alzheimer's Research & Therapy 2012 4:41

    Content type: Research

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  8. Dementia is starting to attract attention following decades of comparative neglect relative to other disease areas. England has been at the forefront of this sea change as one of the first countries in the wor...

    Authors: Zeinab Abdi and Alistair Burns

    Citation: Alzheimer's Research & Therapy 2012 4:36

    Content type: Commentary

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  9. Some familial Alzheimer's disease (AD) cases are caused by rare and highly-penetrant mutations in APP, PSEN1, and PSEN2. Mutations in GRN and MAPT, two genes associated with frontotemporal dementia (FTD), have be...

    Authors: Sheng Chih Jin, Pau Pastor, Breanna Cooper, Sebastian Cervantes, Bruno A Benitez, Cristina Razquin, Alison Goate and Carlos Cruchaga

    Citation: Alzheimer's Research & Therapy 2012 4:34

    Content type: Research

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  10. Chromosome 9 open reading frame 72 (C9orf72) is an evolutionarily conserved protein with unknown function, expressed at high levels in the brain. An expanded hexanucleotide GGGGCC repeat located in the first i...

    Authors: Jun-ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Yuko Saito and Kunimasa Arima

    Citation: Alzheimer's Research & Therapy 2012 4:33

    Content type: Research

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  11. An expanded hexanucleotide repeat in the C9ORF72 gene has recently been identified as an important cause of frontotemporal dementia and motor neuron disease; however, the phenotypic spectrum of this entity and it...

    Authors: Laura E Downey, Colin J Mahoney, Martin N Rossor, Sebastian J Crutch and Jason D Warren

    Citation: Alzheimer's Research & Therapy 2012 4:42

    Content type: Research

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  12. Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of β-amyloid (Aβ) in the brain, which produces progressive neuronal loss and dementia. We recently demonstrated that the...

    Authors: Pedro J Chacón and Alfredo Rodríguez-Tébar

    Citation: Alzheimer's Research & Therapy 2012 4:31

    Content type: Research

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  13. Numerous kindreds with familial frontotemporal dementia or amyotrophic lateral sclerosis or both have been linked to chromosome 9 (c9FTD/ALS), and an expansion of the GGGGCC hexanucleotide repeat in the non-co...

    Authors: Bradley F Boeve and Neill R Graff-Radford

    Citation: Alzheimer's Research & Therapy 2012 4:29

    Content type: Review

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  14. Behavioural and psychological symptoms of dementia (BPS) include depressive symptoms, anxiety, apathy, sleep problems, irritability, psychosis, wandering, elation and agitation, and are common in the non-demen...

    Authors: Rianne M van der Linde, Blossom CM Stephan, George M Savva, Tom Dening and Carol Brayne

    Citation: Alzheimer's Research & Therapy 2012 4:28

    Content type: Research

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  15. Clinical research is best done when aligned with clinical care - that is, when the patient can be identified, recruited and, in many instances, researched in parallel with the delivery of clinical service. How...

    Authors: Piers Kotting, Kris Beicher, Ian G McKeith and Martin N Rossor

    Citation: Alzheimer's Research & Therapy 2012 4:23

    Content type: Review

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  16. Alzheimer's disease is an age-associated, irreversible, progressive neurodegenerative disease that is characterized by severe memory loss, unusual behavior, personality changes, and a decline in cognitive func...

    Authors: Rammohan V Rao, Olivier Descamps, Varghese John and Dale E Bredesen

    Citation: Alzheimer's Research & Therapy 2012 4:22

    Content type: Review

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  17. The current pathological confirmation of the diagnosis of Alzheimer's disease (AD) is still based on postmortem identification of parenchymal amyloid beta (Aβ) plaques, intra-neuronal neurofibrillary tangles, ...

    Authors: Amanda Hanna, Kayleigh Iremonger, Pritam Das, Dennis Dickson, Todd Golde and Christopher Janus

    Citation: Alzheimer's Research & Therapy 2012 4:21

    Content type: Research

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  18. Neuropathological studies have revealed the presence of a broad variety of inflammation-related proteins (complement factors, acute-phase proteins, pro-inflammatory cytokines) in Alzheimer's disease (AD) brain...

    Authors: Piet Eikelenboom, Jeroen JM Hoozemans, Rob Veerhuis, Eric van Exel, Annemieke JM Rozemuller and Willem A van Gool

    Citation: Alzheimer's Research & Therapy 2012 4:15

    Content type: Review

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  19. A hallmark of Alzheimer's disease (AD) is the presence of senile plaques composed of aggregated amyloid β (Aβ) peptides. Pathological aging (PA) is a postmortem classification that has been used to describe br...

    Authors: Brenda D Moore, Paramita Chakrabarty, Yona Levites, Tom L Kukar, Ann-Marie Baine, Tina Moroni, Thomas B Ladd, Pritam Das, Dennis W Dickson and Todd E Golde

    Citation: Alzheimer's Research & Therapy 2012 4:18

    Content type: Research

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  20. The low-density lipoprotein receptor-related protein (LRP1) and its family members have been implicated in the pathogenesis of Alzheimer's disease. Multiple susceptibility factors converge to metabolic pathway...

    Authors: Guilian Xu, Cameron C Green, Susan E Fromholt and David R Borchelt

    Citation: Alzheimer's Research & Therapy 2012 4:12

    Content type: Research

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  21. Previous work indicates that resting-state functional magnetic resonance imaging (fMRI) is sensitive to functional brain changes related to Alzheimer's disease (AD) pathology across the clinical spectrum. Cros...

    Authors: Jessica S Damoiseaux

    Citation: Alzheimer's Research & Therapy 2012 4:8

    Content type: Commentary

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  22. Dementia, a major cause of disability and institutionalization in older people, poses a serious threat to public health and to the social and economic development of modern society. Alzheimer's disease (AD) an...

    Authors: Francesca Mangialasche, Miia Kivipelto, Alina Solomon and Laura Fratiglioni

    Citation: Alzheimer's Research & Therapy 2012 4:6

    Content type: Review

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  23. Alzheimer's disease (AD) is a cognitive disorder with a number of complex neuropathologies, including, but not limited to, neurofibrillary tangles, neuritic plaques, neuronal shrinkage, hypomyelination, neuroi...

    Authors: Paul L Wood

    Citation: Alzheimer's Research & Therapy 2012 4:5

    Content type: Review

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  24. Frontotemporal lobar degeneration (FTLD) is a devastating neurodegenerative disease that is the second most common form of dementia affecting individuals under age 65. The most common pathological subtype, FTL...

    Authors: Alexandra M Nicholson, Jennifer Gass, Leonard Petrucelli and Rosa Rademakers

    Citation: Alzheimer's Research & Therapy 2012 4:4

    Content type: Review

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  25. Resting-state functional magnetic resonance imaging (fMRI) is emerging as an interesting biomarker for measuring connectivity of the brain in patients with Alzheimer's disease (AD). In this review, we discuss ...

    Authors: Prashanthi Vemuri, David T Jones and Clifford R Jack Jr

    Citation: Alzheimer's Research & Therapy 2012 4:2

    Content type: Review

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  26. Recent epidemiologic studies have noted that risk factors for atherosclerosis (for example, diabetes mellitus, hypertension, and hyperlipidemia) are associated with increased risk of incident Alzheimer's disea...

    Authors: Helena C Chui, Ling Zheng, Bruce R Reed, Harry V Vinters and Wendy J Mack

    Citation: Alzheimer's Research & Therapy 2012 3:1

    Content type: Review

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  27. Although the molecular mechanisms underlying the pathogenesis of Alzheimer's disease and other related neurodegenerative diseases remain unclear, accumulation of misfolded proteins, neuroinflammation, mitochon...

    Authors: Rachel F Lane, Diana W Shineman and Howard M Fillit

    Citation: Alzheimer's Research & Therapy 2011 3:36

    Content type: Meeting report

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  28. Patient-reported outcome (PRO) measures are used to evaluate disease and treatments in many therapeutic areas, capturing relevant aspects of the disorder not obtainable through clinician or informant report, i...

    Authors: Lori Frank, William R Lenderking, Kellee Howard and Marc Cantillon

    Citation: Alzheimer's Research & Therapy 2011 3:35

    Content type: Review

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