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  1. Content type: Research

    Subjective cognitive decline (SCD) defines a heterogeneous population, part of which having Alzheimer’s disease (AD). We aimed at characterizing SCD populations according to whether or not they referred to a m...

    Authors: Elizabeth Kuhn, Inès Moulinet, Audrey Perrotin, Renaud La Joie, Brigitte Landeau, Clémence Tomadesso, Alexandre Bejanin, Siya Sherif, Vincent De La Sayette, Béatrice Desgranges, Denis Vivien, Géraldine Poisnel and Gaëlle Chételat

    Citation: Alzheimer's Research & Therapy 2019 11:61

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  2. Content type: Research

    Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim of th...

    Authors: Tessa Timmers, Rik Ossenkoppele, Emma E. Wolters, Sander C. J. Verfaillie, Denise Visser, Sandeep S. V. Golla, Frederik Barkhof, Philip Scheltens, Ronald Boellaard, Wiesje M. van der Flier and Bart N. M. van Berckel

    Citation: Alzheimer's Research & Therapy 2019 11:60

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  3. Content type: Research

    The earliest brain pathology related to Alzheimer’s disease (AD) is hyperphosphorylated soluble tau in the noradrenergic locus coeruleus (LC) neurons. Braak characterizes five pretangle tau stages preceding AD...

    Authors: Abhinaba Ghosh, Sarah E. Torraville, Bandhan Mukherjee, Susan G. Walling, Gerard M. Martin, Carolyn W. Harley and Qi Yuan

    Citation: Alzheimer's Research & Therapy 2019 11:59

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  4. Content type: Research

    Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction ...

    Authors: Leslie A. Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T. Calahatian, Devon S. Placides, Mallory D. Watler, Jerry B. Hunt, April L. Darling, Jeremy D. Baker, Laura J. Blair, Mackenzie D. Martin, Sarah N. Fontaine, Chad A. Dickey, April L. Lussier, Edwin J. Weeber, Maj-Linda B. Selenica…

    Citation: Alzheimer's Research & Therapy 2019 11:58

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  5. Content type: Research

    Reduced 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) brain metabolism was recognized as a biomarker of neurodegeneration in the recently proposed ATN framework for Alzheimer’s disease (AD) biolog...

    Authors: Ya-Nan Ou, Wei Xu, Jie-Qiong Li, Yu Guo, Mei Cui, Ke-Liang Chen, Yu-Yuan Huang, Qiang Dong, Lan Tan and Jin-Tai Yu

    Citation: Alzheimer's Research & Therapy 2019 11:57

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  6. Content type: Research

    Intracerebral inoculation of extracts from post-mortem human Alzheimer’s disease brains into mice produces a prion-like spreading effect of amyloid-β. The differences observed between these extracts and the sy...

    Authors: Cristina M. Pedrero-Prieto, Alicia Flores-Cuadrado, Daniel Saiz-Sánchez, Isabel Úbeda-Bañón, Javier Frontiñán-Rubio, Francisco J. Alcaín, Lourdes Mateos-Hernández, José de la Fuente, Mario Durán-Prado, Margarita Villar, Alino Martínez-Marcos and Juan R. Peinado

    Citation: Alzheimer's Research & Therapy 2019 11:56

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  7. Content type: Research

    Age-related frailty reflects cumulative multisystem physiological and health decline. Frailty increases the risk of adverse brain and cognitive outcomes, including differential decline and dementia. In a longi...

    Authors: Sherilyn Thibeau, Kirstie McDermott, G. Peggy McFall, Kenneth Rockwood and Roger A. Dixon

    Citation: Alzheimer's Research & Therapy 2019 11:55

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  8. Content type: Research

    Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine. Chronic inflammation induced by amyloid β proteins (Aβ) is one prominent neuropathological feature in Alzheimer’s disease (AD) brain.

    Authors: Si Zhang, Jiehao Zhao, Yuhu Zhang, Yun Zhang, Fang Cai, Lijuan Wang and Weihong Song

    Citation: Alzheimer's Research & Therapy 2019 11:54

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  9. Content type: Research

    The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported beneficial effects on cognition for a 2-year multimo...

    Authors: Ruth Stephen, Yawu Liu, Tiia Ngandu, Riitta Antikainen, Juha Hulkkonen, Juha Koikkalainen, Nina Kemppainen, Jyrki Lötjönen, Esko Levälahti, Riitta Parkkola, Pauliina Pippola, Juha Rinne, Timo Strandberg, Jaakko Tuomilehto, Ritva Vanninen, Miia Kivipelto…

    Citation: Alzheimer's Research & Therapy 2019 11:53

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  10. Content type: Letter

    Authors: Carl Taswell, Cheryl Donohue, Maree T. Mastwyk, Andrea G. Louey, Jacqueline Giummarra, Joanne Robertson, David G. Darby, Colin L. Masters and Christopher C. Rowe

    Citation: Alzheimer's Research & Therapy 2019 11:52

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    The original article was published in Alzheimer's Research & Therapy 2018 10:125

    The Letter Response to this article has been published in Alzheimer's Research & Therapy 2019 11:51

  11. Content type: Research

    Subjective cognitive decline (SCD) is characterized by self-reported cognitive deficits without measurable cognitive impairment. It has been suggested that individuals with SCD exhibited brain structural alter...

    Authors: Yu Sun, Xiaoni Wang, Yinshan Wang, Haoming Dong, Jie Lu, Tohar Scheininger, Michael Ewers, Frank Jessen, Xi-Nian Zuo and Ying Han

    Citation: Alzheimer's Research & Therapy 2019 11:50

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  12. Content type: Research

    Alzheimer’s disease (AD) prevalence is rapidly growing as worldwide populations grow older. Available treatments have failed to slow down disease progression, thus increasing research focus towards early or pr...

    Authors: David López-Sanz, Ricardo Bruña, María Luisa Delgado-Losada, Ramón López-Higes, Alberto Marcos-Dolado, Fernando Maestú and Stefan Walter

    Citation: Alzheimer's Research & Therapy 2019 11:49

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  13. Content type: Research

    Neuropsychiatric symptoms (NPS) are very common in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia and are associated with various disadvantageous clinical outcomes includin...

    Authors: Willem S. Eikelboom, Ellen Singleton, Esther van den Berg, Michiel Coesmans, Francesco Mattace Raso, Rozemarijn L. van Bruchem, Jeannette A. Goudzwaard, Frank Jan de Jong, Marc Koopmanschap, Tom den Heijer, Jan J. M. Driesen, Lilian J. H. M. Vroegindeweij, Elsbeth C. Thomeer, Susanne E. Hoogers, Anke A. Dijkstra, Sytse U. Zuidema…

    Citation: Alzheimer's Research & Therapy 2019 11:48

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  14. Content type: Research

    There is increasing evidence that dementia risk associated with vascular disorders is age dependent. Large population-based studies of incident dementia are necessary to further elucidate this effect. Therefor...

    Authors: Nienke Legdeur, Sven J. van der Lee, Marcel de Wilde, Johan van der Lei, Majon Muller, Andrea B. Maier and Pieter Jelle Visser

    Citation: Alzheimer's Research & Therapy 2019 11:47

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  15. Content type: Research

    Several evidences suggest that failure of synaptic function occurs at preclinical stages of Alzheimer’s disease (AD) preceding neuronal loss and the classical AD pathological hallmarks. Nowadays, there is an u...

    Authors: Dolores Siedlecki-Wullich, Judit Català-Solsona, Cristina Fábregas, Isabel Hernández, Jordi Clarimon, Alberto Lleó, Merce Boada, Carlos A. Saura, José Rodríguez-Álvarez and Alfredo J. Miñano-Molina

    Citation: Alzheimer's Research & Therapy 2019 11:46

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  16. Content type: Research

    The cognitive-functional composite (CFC) was designed to improve the measurement of clinically relevant changes in predementia and early dementia stages. We have previously demonstrated its good test-retest re...

    Authors: Roos J. Jutten, John E. Harrison, Philippe R. Lee Meeuw Kjoe, Silvia Ingala, R. Vreeswijk, R. A. J. van Deelen, Frank Jan de Jong, Esther M. Opmeer, André Aleman, Craig W. Ritchie, Philip Scheltens and Sietske A. M. Sikkes

    Citation: Alzheimer's Research & Therapy 2019 11:45

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  17. Content type: Research

    Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss. The majority of AD patients also have Aβ deposition in cereb...

    Authors: Emily B. Button, Guilaine K. Boyce, Anna Wilkinson, Sophie Stukas, Arooj Hayat, Jianjia Fan, Brennan J. Wadsworth, Jerome Robert, Kris M. Martens and Cheryl L. Wellington

    Citation: Alzheimer's Research & Therapy 2019 11:44

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  18. Content type: Research

    Studies in older adults or those with cognitive impairment have shown associations between cognitive and olfactory performance, but there are few population-based studies especially in younger adults. We there...

    Authors: Maryam Yahiaoui-Doktor, Tobias Luck, Steffi G. Riedel-Heller, Markus Loeffler, Kerstin Wirkner and Christoph Engel

    Citation: Alzheimer's Research & Therapy 2019 11:43

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  19. Content type: Research

    ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer’s disease has been widely studied, ...

    Authors: Sofía Fernández de Retana, Paula Marazuela, Montse Solé, Guillem Colell, Anna Bonaterra, Jose Luis Sánchez-Quesada, Joan Montaner, Daniel Maspoch, Mary Cano-Sarabia and Mar Hernández-Guillamon

    Citation: Alzheimer's Research & Therapy 2019 11:42

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  20. Content type: Research

    Semantic variant of primary progressive aphasia (svPPA) is a subtype of frontotemporal dementia characterized by asymmetric temporal atrophy.

    Authors: Martina Bocchetta, Juan Eugenio Iglesias, Lucy L. Russell, Caroline V. Greaves, Charles R. Marshall, Marzia A. Scelsi, David M. Cash, Sebastien Ourselin, Jason D. Warren and Jonathan D. Rohrer

    Citation: Alzheimer's Research & Therapy 2019 11:41

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  21. Content type: Research

    Oligomeric amyloid-ß is a major toxic species associated with Alzheimer’s disease pathogenesis. Methods used to measure oligomeric amyloid-β in the blood have increased in number in recent years. The Multimer ...

    Authors: Young Chul Youn, Sungmin Kang, Jeewon Suh, Young Ho Park, Min Ju Kang, Jung-Min Pyun, Seong Hye Choi, Jee Hyang Jeong, Kyung Won Park, Ho-Won Lee, Seong Soo A. An, Jacqueline C. Dominguez and SangYun Kim

    Citation: Alzheimer's Research & Therapy 2019 11:40

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  22. Content type: Correction

    Following publication of the original article [1], the authors reported that Fig. 6 contains a mistake. The Fig. 6F is a duplicate of Fig. 6E of Braak 5.

    Authors: Akitoyo Hishimoto, Olga Pletnikova, Doyle Lu Lang, Juan C. Troncoso, Josephine M. Egan and Qing-Rong Liu

    Citation: Alzheimer's Research & Therapy 2019 11:39

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    The original article was published in Alzheimer's Research & Therapy 2019 11:28

  23. Content type: Research

    Discrepant and often contradictory results have accumulated regarding the antidepressant and pro-cognitive effects of serotonin transporter (SERT) antagonists in Alzheimer’s disease.

    Authors: Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M. Landau and Bente Finsen

    Citation: Alzheimer's Research & Therapy 2019 11:38

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  24. Content type: Research

    High-dose donepezil is currently prescribed for patients with Alzheimer’s disease (AD) who showed poor or waning response to a lower dose at the risk of increasing cholinergic side effects. However, the advers...

    Authors: Yun Jeong Hong, Hyun Jeong Han, Young Chul Youn, Kyung Won Park, Dong Won Yang, SangYun Kim, Hwa Jung Kim, Ji Eun Kim and Jae-Hong Lee

    Citation: Alzheimer's Research & Therapy 2019 11:37

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  25. Content type: Research

    Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues. This trial aims to contribute to the establishment of...

    Authors: Miranka Wirth, Claudia Schwarz, Gloria Benson, Nora Horn, Ralph Buchert, Catharina Lange, Theresa Köbe, Stefan Hetzer, Marta Maglione, Eva Michael, Stefanie Märschenz, Knut Mai, Ute Kopp, Dietmar Schmitz, Ulrike Grittner, Stephan J. Sigrist…

    Citation: Alzheimer's Research & Therapy 2019 11:36

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  26. Content type: Research

    Alzheimer’s disease (AD) is responsible for 60–70% of all cases of dementia. On the other hand, the tap water consumed by hundreds of millions of people has been fluoridated to prevent tooth decay. However, li...

    Authors: Kun Cao, Jie Xiang, Yang-Ting Dong, Yi Xu, Yi Li, Hui Song, Xiao-Xiao Zeng, Long-Yan Ran, Wei Hong and Zhi-Zhong Guan

    Citation: Alzheimer's Research & Therapy 2019 11:35

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  27. Content type: Review

    The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ42), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau181) have proven diagnostic accuracy for mild cognitive impairmen...

    Authors: Oskar Hansson, Sylvain Lehmann, Markus Otto, Henrik Zetterberg and Piotr Lewczuk

    Citation: Alzheimer's Research & Therapy 2019 11:34

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  28. Content type: Research

    Biomarkers such as cerebrospinal fluid (CSF) and magnetic resonance imaging (MRI) have predictive value for progression to dementia in patients with mild cognitive impairment (MCI). The pre-dementia stage take...

    Authors: Ingrid S. van Maurik, Rosalinde E. R. Slot, Sander C. J. Verfaillie, Marissa D. Zwan, Femke H. Bouwman, Niels D. Prins, Charlotte E. Teunissen, Philip Scheltens, Frederik Barkhof, Mike P. Wattjes, Jose Luis Molinuevo, Lorena Rami, Steffen Wolfsgruber, Oliver Peters, Frank Jessen, Johannes Berkhof…

    Citation: Alzheimer's Research & Therapy 2019 11:33

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  29. Content type: Research

    The leading causes of death among the elderly with cognitive impairment are unknown. This study aims to estimate the suicide and accidental death rates on the basis of a clinical case registry of patients diag...

    Authors: Ji Hyun An, Kyung Eun Lee, Hong Jin Jeon, Sang Joon Son, Sung Yoon Kim and Jin Pyo Hong

    Citation: Alzheimer's Research & Therapy 2019 11:32

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  30. Content type: Research

    Dementia is prevalent in the end-stage renal disease (ESRD) population. However, it is still not clarified whether ESRD is one of the etiology of dementia or its attributable effect on the cumulative risk of d...

    Authors: Yi-Ting Kuo, Chung-Yi Li, Junne-Ming Sung, Chiung-Chih Chang, Jung-Der Wang, Chien-Yao Sun, Jia-Ling Wu and Yu-Tzu Chang

    Citation: Alzheimer's Research & Therapy 2019 11:31

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  31. Content type: Review

    The phenocopy syndrome of behavioral variant of frontotemporal dementia (phFTD) refers to patients presenting with neuropsychiatric symptoms mimicking the behavioral variant frontotemporal dementia (bvFTD), bu...

    Authors: Elizabeth Sakamoto Valente, Paulo Caramelli, Leandro Boson Gambogi, Luciano Inácio Mariano, Henrique Cerqueira Guimarães, Antônio Lúcio Teixeira and Leonardo Cruz de Souza

    Citation: Alzheimer's Research & Therapy 2019 11:30

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  32. Content type: Research

    Alzheimer’s disease (AD) is the sixth leading cause of death, with an average survival estimated between 5 and 10 years after diagnosis. Despite recent advances in diagnostic criteria of AD, few studies have u...

    Authors: Adla Boumenir, Emmanuel Cognat, Severine Sabia, Claire Hourregue, Matthieu Lilamand, Aline Dugravot, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Jacques Hugon, Archana Singh-Manoux, Claire Paquet and Julien Dumurgier

    Citation: Alzheimer's Research & Therapy 2019 11:29

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  33. Content type: Research

    Synaptic damage precedes neuron death in Alzheimer’s disease (AD). Neurexins, NRXN1, NRXN2, and NRXN3, are presynaptic adhesion molecules that specify neuron synapses and regulate neurotransmitter release. Neurex...

    Authors: Akitoyo Hishimoto, Olga Pletnikova, Doyle Lu Lang, Juan C. Troncoso, Josephine M. Egan and Qing-Rong Liu

    Citation: Alzheimer's Research & Therapy 2019 11:28

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    The Correction to this article has been published in Alzheimer's Research & Therapy 2019 11:39

  34. Content type: Research

    The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making fo...

    Authors: Gemma Salvadó, José Luis Molinuevo, Anna Brugulat-Serrat, Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Javier Pavia, Aida Niñerola-Baizán, Andrés Perissinotti, Francisco Lomeña, Carolina Minguillon, Karine Fauria, Henrik Zetterberg, Kaj Blennow and Juan Domingo Gispert

    Citation: Alzheimer's Research & Therapy 2019 11:27

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  35. Content type: Research

    Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an ultra-high risk of dementia due to Alzheimer’s disease (AD), driven by amyloid precursor protein (APP) gene triplication. Understanding r...

    Authors: Carla M. Startin, Nicholas J. Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K. Wiseman, Kin Y. Mok, John Hardy, Alberto Lleó, Simon Lovestone, Lucilla Parnetti, Henrik Zetterberg, Abdul Hye and André Strydom

    Citation: Alzheimer's Research & Therapy 2019 11:26

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  36. Content type: Research

    In clinical practice, it is often difficult to predict which patients with cognitive complaints or impairment will progress or remain stable. We assessed the impact of using a clinical decision support system,...

    Authors: Marie Bruun, Kristian S. Frederiksen, Hanneke F. M. Rhodius-Meester, Marta Baroni, Le Gjerum, Juha Koikkalainen, Timo Urhemaa, Antti Tolonen, Mark van Gils, Daniel Rueckert, Nadia Dyremose, Birgitte B. Andersen, Afina W. Lemstra, Merja Hallikainen, Sudhir Kurl, Sanna-Kaisa Herukka…

    Citation: Alzheimer's Research & Therapy 2019 11:25

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  37. Content type: Research

    Although previous studies have revealed many factors related to mild cognitive impairment (MCI) reversion, information about reversible factors related MCI reversion is limited, impeding the development of int...

    Authors: Hiroyuki Shimada, Takehiko Doi, Sangyoon Lee and Hyuma Makizako

    Citation: Alzheimer's Research & Therapy 2019 11:24

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  38. Content type: Meeting report

    The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator’s meeting was held on December 14, 2017, in New Orleans. The program was established to increase patient acces...

    Authors: Bethany Peterson, Melissa Armstrong, Douglas Galasko, James E. Galvin, Jennifer Goldman, David Irwin, Henry Paulson, Daniel Kaufer, James Leverenz, Angela Lunde, Ian G. McKeith, Andrew Siderowf, Angela Taylor, Katherine Amodeo, Matt Barrett, Kimiko Domoto-Reilly…

    Citation: Alzheimer's Research & Therapy 2019 11:23

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  39. Content type: Commentary

    A primary goal of research in cognitive impairment and dementia is to understand how some individuals retain sufficient cognitive function for a fulfilling life while many others are robbed of their independen...

    Authors: Thomas J. Montine, Brenna A. Cholerton, Maria M. Corrada, Steven D. Edland, Margaret E. Flanagan, Laura S. Hemmy, Claudia H. Kawas and Lon R. White

    Citation: Alzheimer's Research & Therapy 2019 11:22

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  40. Content type: Review

    The objective of this systematic review was (1) to give an overview of the available short screening instruments for the early detection of Alzheimer’s disease (AD) and (2) to review the psychometric propertie...

    Authors: Ellen Elisa De Roeck, Peter Paul De Deyn, Eva Dierckx and Sebastiaan Engelborghs

    Citation: Alzheimer's Research & Therapy 2019 11:21

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  41. Content type: Research

    [18F]FDG-PET hypometabolism patterns are indicative of different neurodegenerative conditions, even from the earliest disease phase. This makes [18F]FDG-PET a valuable tool in the diagnostic workup of neurodeg...

    Authors: Silvia Paola Caminiti, Arianna Sala, Leonardo Iaccarino, Luca Beretta, Andrea Pilotto, Luigi Gianolli, Sandro Iannaccone, Giuseppe Magnani, Alessandro Padovani, Luigi Ferini-Strambi and Daniela Perani

    Citation: Alzheimer's Research & Therapy 2019 11:20

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  42. Content type: Research

    To investigate how serum neurofilament light (NfL) concentration changes through the course of disease in familial Alzheimer’s disease (FAD) and to assess when NfL concentration first increases.

    Authors: Philip S. J. Weston, Teresa Poole, Antoinette O’Connor, Amanda Heslegrave, Natalie S. Ryan, Yuying Liang, Ronald Druyeh, Simon Mead, Kaj Blennow, Jonathan M. Schott, Chris Frost, Henrik Zetterberg and Nick C. Fox

    Citation: Alzheimer's Research & Therapy 2019 11:19

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  43. Content type: Research

    There are currently no approved treatments for the prodromal stage of Alzheimer’s disease (AD). Approved symptomatic treatments for mild-to-moderate AD include acetylcholinesterase inhibitors and memantine, bu...

    Authors: Lutz Frölich, Glen Wunderlich, Claus Thamer, Michael Roehrle, Miguel Garcia Jr and Bruno Dubois

    Citation: Alzheimer's Research & Therapy 2019 11:18

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  44. Content type: Research

    Autosomal dominant Alzheimer’s disease (ADAD) is distinguished from late-onset AD by early striatal amyloid-β deposition. To determine whether striatal Pittsburgh compound B (PiB)-PET measurements of amyloid-β...

    Authors: Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Daniel J. Norton, Edmarie Guzman-Velez, Ana Baena, Enmanuelle Pardilla-Delgado, Aaron P. Schultz, Jennifer Gatchel, David Jin, Kewei Chen, Eric M. Reiman, Keith A. Johnson and Yakeel T. Quiroz

    Citation: Alzheimer's Research & Therapy 2019 11:17

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  45. Content type: Research

    Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset Alzheimer’s disease (LOAD). Amongst these, a polymorphism in phospholipase C-...

    Authors: Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E. Golde and Paul J. Whiting

    Citation: Alzheimer's Research & Therapy 2019 11:16

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  46. Content type: Research

    Current methods of amyloid PET interpretation based on the binary classification of global amyloid signal fail to identify early phases of amyloid deposition. A recent analysis of 18F-florbetapir PET data from...

    Authors: Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Irina Jelistratova, Marie-Odile Habert, Martin Dyrba, Gabriel Gonzalez-Escamilla, Hugo Bertin, Maxime Locatelli, Stephane Lehericy, Stefan Teipel, Bruno Dubois and Harald Hampel

    Citation: Alzheimer's Research & Therapy 2019 11:15

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  47. Content type: Research

    A decline in instrumental activities of daily living (IADL) correlates with the progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia and has been associated with frontal and pa...

    Authors: Omar A. Halawa, Jennifer R. Gatchel, Rebecca E. Amariglio, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson and Gad A. Marshall

    Citation: Alzheimer's Research & Therapy 2019 11:14

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  48. Content type: Research

    The tau positron emission tomography (PET) ligand 18F-flortaucipir binds to paired helical filaments of tau in aging and Alzheimer’s disease (AD), but its utility in detecting tau aggregates in frontotemporal dem...

    Authors: Richard M. Tsai, Alexandre Bejanin, Orit Lesman-Segev, Renaud LaJoie, Adrienne Visani, Viktoriya Bourakova, James P. O’Neil, Mustafa Janabi, Suzanne Baker, Suzee E. Lee, David C. Perry, Lynn Bajorek, Anna Karydas, Salvatore Spina, Lea T. Grinberg, William W. Seeley…

    Citation: Alzheimer's Research & Therapy 2019 11:13

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  49. Content type: Research

    White matter hyperintensities (WMH) of presumed vascular origin have been associated with an increased risk of Alzheimer’s disease (AD). This study aims to describe the patterns of WMH associated with dementia...

    Authors: Gemma Salvadó, Anna Brugulat-Serrat, Carole H. Sudre, Oriol Grau-Rivera, Marc Suárez-Calvet, Carles Falcon, Karine Fauria, M. Jorge Cardoso, Frederik Barkhof, José Luis Molinuevo and Juan Domingo Gispert

    Citation: Alzheimer's Research & Therapy 2019 11:12

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