Skip to main content

Table 3 Higher WMH volumes are associated with worse and worsening cognitive performance

From: Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study

 

WMH volumea

Baseline (n = 375)

Longitudinal (n = 226)

Memory

Executive

PACC5

ΔPACC5

B (SE); pFDR

B (SE); pFDR

B (SE); pFDR

B (SE); pFDR

 

Global

 − 0.10 (0.03); < 0.001

 − 0.08 (0.03); 0.005

 − 0.10 (0.03); 0.001

 − 0.16 (0.05); 0.001

Lobes

Frontal

 − 0.04 (0.05); 0.012

 − 0.03 (0.02); 0.028

 − 0.04 (0.02); 0.008

 − 0.09 (0.03); 0.004

Temporal

 − 0.07 (0.02); 0.001

 − 0.05 (0.02); 0.007

 − 0.07 (0.02); < 0.001

 − 0.13 (0.04); < 0.001

Occipital

 − 0.04 (0.02); 0.006

 − 0.02 (0.02); 0.335

 − 0.03 (0.02); 0.078

 − 0.10 (0.03); 0.001

Parietal

 − 0.04 (0.01); 0.002

 − 0.03 (0.01); 0.040

 − 0.04 (0.01); 0.005

 − 0.06 (0.03); 0.025

Tracts

Corona radiata

 − 0.05 (0.01); 0.001

 − 0.04 (0.02); 0.008

 − 0.05 (0.02); 0.003

 − 0.08 (0.03); 0.004

External capsule

 − 0.03 (0.02); 0.142

 − 0.00 (0.02); 0.893

 − 0.03 (0.02); 0.107

 − 0.07 (0.04); 0.103

Internal capsule

 − 0.05 (0.02); 0.004

 − 0.05 (0.02); 0.005

 − 0.06 (0.02); 0.002

 − 0.08 (0.03); 0.016

Optic radiation

 − 0.05 (0.01); 0.001

 − 0.02 (0.01); 0.198

 − 0.04 (0.01); 0.010

 − 0.09 (0.03); 0.001

Corpus callosum

Genu

 − 0.07 (0.02); 0.004

 − 0.04 (0.02); 0.057

 − 0.06 (0.02); 0.016

 − 0.11 (0.04); 0.004

Body

 − 0.11 (0.03); < 0.001

 − 0.10 (0.03); < 0.001

 − 0.11 (0.03); < 0.001

 − 0.16 (0.05); 0.001

Splenium

 − 0.10 (0.02); < 0.001

 − 0.08 (0.02); 0.001

 − 0.10 (0.02); < 0.001

 − 0.13 (0.04); 0.002

  1. We used multiple linear regression to probe the relationship between regional WMH volume (dependent variable) and cognitive performance (independent variable). We created separate models for each region of interest and each measure of cognitive performance. We adjusted for hypertension, Aβ positivity, age, sex, education, mean background intensity, and total intracranial volume. We print pFDR < 0.05 in bold
  2. aWe log-transformed WMH volumes to deal with skewness
  3. pFDR, p-values after adjusting for multiple comparisons using FDR; n sample size, B regression coefficient, SE standard error