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Table 2 Subjects with hypertension and Aβ positivity present the largest frontal, parietal, and occipital WMH volumes

From: Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study

 

WMH volumea

Hypertension

Aβ positivity

B (SE)

pFDR

B (SE)

pFDR

 

Global

0.23 (0.09)

0.030

0.22 (0.10)

0.044

Lobes

Frontal

0.42 (0.17)

0.021

0.46 (0.18)

0.021

Temporal

0.14 (0.14)

0.447

0.22 (0.15)

0.268

Occipital

0.50 (0.16)

0.003

0.50 (0.16)

0.004

Parietal

0.57 (0.18)

0.005

0.56 (0.20)

0.008

Tracts

Corona radiata

0.45 (0.17)

0.020

0.40 (0.13)

0.046

External capsule

0.21 (0.13)

0.171

0.27 (0.13)

0.096

Internal capsule

0.22 (0.14)

0.209

0.07 (0.15)

0.741

Optic radiation

0.39 (0.18)

0.041

0.74 (0.19)

0.001

Corpus callosum

Genu

0.23 (0.11)

0.087

0.07 (0.12)

0.641

Body

0.21 (0.10)

0.053

0.15 (0.10)

0.212

Splenium

0.36 (0.12)

0.005

0.28 (0.12)

0.038

  1. We built multiple linear regression models to examine regional WMH volume (outcome) in relation to hypertension and Aβ positivity (factors)—one for each region of interest. We controlled for age, sex, education, mean background intensity, and total intracranial volume. We print pFDR < 0.05 in bold
  2. aWe log-transformed WMH volumes to deal with skewness
  3. pFDR, p-values after adjusting for multiple comparisons using FDR; B, regression coefficient; SE standard error