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Table 1 Characteristics of the memory clinic cohorts

From: The reporting of neuropsychiatric symptoms in electronic health records of individuals with Alzheimer’s disease: a natural language processing study

 

Alzheimer Center Amsterdam

Alzheimer Center Erasmus MC

N patients

3001

646

Age, mean (SD)a

67.2 (8.6)

71.1 (9.3)***

Sex, N (%) female

1571 (52.4%)

323 (50.0%)

Education, median (IQR)b

5.0 (2.0)

5.0 (2.0)

Whites, N (%)c

189 (90.0%)

345 (89.1%)

MMSE, mean (SD)d

21.1 (6.4)

21.6 (5.5)

Diagnosis, N (%)

Mild cognitive impairment

436 (14.5%)

157 (24.3%)***

AD dementia

2438 (81.2%)

422 (65.3%)***

AD/VaD dementia

127 (4.2%)

67 (10.4%)***

Amyloid-beta positive, N (%)e

2092 (69.7%)

184 (28.5%)***

NPI or NPI-Q available, N (%)

2022 (67.4%)

133 (20.6%)***

  1. Abbreviations: AD Alzheimer’s disease, MMSE Mini-Mental State Examination, NPI Neuropsychiatric Inventory, NPI-Q Neuropsychiatric Inventory questionnaire, VaD vascular dementia
  2. *** p < 0.001
  3. aData missing for n = 79 (Erasmus MC)
  4. bDutch education system categorized into (1) less than 6 years primary education [< 6 years], (2) completed primary education [6 years], (3) more than 6 years of primary education, without a secondary school diploma [8 years], (4) lower vocational training [9 years], (5) advanced vocational training or lower professional education [10–11 years], (6) advanced professional training or upper secondary school [12–18 years], and (7) academic degree [> 18 years]. Data missing for n = 261 (Amsterdam UMC) and n = 306 (Erasmus MC)
  5. cData missing for n = 2792 (Amsterdam UMC) and n = 259 (Erasmus MC)
  6. dData missing for n = 253 (Amsterdam UMC) and n = 125 (Erasmus MC)
  7. eBased on either cerebrospinal fluid (i.e., amyloid-beta42 < 550 pg/mL or tau/amyloid-beta42 ratio > 0.52) or visual rating of an amyloid-beta PET scan