Table 1 Main demographic, clinical, biological, and imaging characteristics at baseline and neuropsychological, tau-PET, and MRI data at 1 and 2 years (mean (SD))

Demographic data

Age (years)

68.6 (6.7)

68.7 (3.4)

-

-

-

-

Sex (F/M)

14/13

9/3

-

-

-

-

Education (years)

14.5 (4.4)

14.6 (3.3)

-

-

-

-

Disease duration (years)

4.3 (3.6)

NA

-

-

-

-

Cholinesterase inhibitors (n)

21

-

Introduced in 1, discontinued in 2

-

Introduced in 1

-

Functional status

CDR

0

0

12

0

12

0

12

0.5

23

0

10

0

4

0

1

4

0

17

0

16

0

2

0

0

0

0

7

0

3

0

0

0

0

0

0

CDR sum of boxes

3.5 (1.8)

0

5 (2)

0

6.8 (2.7)

0

Neuropsychological assessment

 Global cognitive efficiency

MMSE (/30)

23.5 (3.1)^#

28.8 (1.1)

21.6 (3.9)

29.3 (0.7)

18.8 (5.7)*

29.8 (0.5)

 Memory score

FCSRT (free + total immediate and delayed recalls) (/128)

58.9 (27.4)^#

108.8 (6.5)

43.9 (29.9)

110.4 (9)

28 (27.8)*

109.8 (5.3)

 Instrumental score

(Naming + praxis + Rey figure copy) (/188)

169.8 (19.6)

185.1 (1.7)

160.2 (29.3)

185.8 (1.9)

145.6 (37.6)*

185.8 (2.7)

 Executive score

(Digit spans + letter fluency 2 min + WAIS similarities)

43.4 (12.6)^#

69.6 (7.9)

42.1 (15.4)

64.1 (11.1)

38.5 (18.8)

62.2 (11.3)

Genetic status

ApoE genotype (n with at least one E4 allele)

20

2

-

-

-

-

CSF biomarkers^&

Amyloid peptide (pg/mL)

471.5 (113.7)

NA

-

-

-

-

Total Tau (pg/mL)

640.5 (392.1)

NA

-

-

-

-

Phospho-tau181 (pg/mL)

87.1 (37.1)

NA

-

-

-

-

Molecular PET imaging

PiB-PET SUVr (GCI)

2.89 (0.68)^#

1.25 (0.08)

-

-

-

-

Mean Tau-PET SUVr (infero-medial temporal meta-VOI)

1.57 (0.35)^#

0.96 (0.08)

-

-

1.64 (0.25)

0.97 (0.06)

Mean Tau-PET SUVr (lateral temporal VOI)

1.49 (0.33)^#

0.97 (0.08)

-

-

1.53 (0.23)

0.98 (0.06)

Mean Tau-PET SUVr (lateral parietal VOI)

1.51 (0.50)^#

0.92 (0.07)

-

-

1.52 (0.38)

0.94 (0.07)

Mean Tau-PET SUVr (medial parietal VOI)

1.52 (0.55)^#

0.91 (0.09)

-

-

1.58 (0.46)

0.93 (0.06)

Mean Tau-PET SUVr (frontal VOI)

1.17 (0.23)^#

0.95 (0.07)

1.24 (0.26)

0.96 (0.08)

MRI

Fazekas score (0/1/2/3)

14/9/3/1

8/4/0/0

-

-

-

-

Mean normalized HV

2.04 (0.30)^#

2.41 (0.20)

-

-

1.9 (0.28)*

2.39 (0.25)

Mean infero-medial temporal VOI CT (mm)

2.54 (0.18)^#

2.86 (0.13)

-

-

2.38 (0.20)*

2.83 (0.14)

Mean lateral temporal VOI CT (mm)

2.5 (0.14)^#

2.78 (0.15)

-

-

2.35 (0.18)*

2.75 (0.15)

Mean lateral parietal VOI CT (mm)

2.05 (0.20)^#

2.35 (0.16)

-

-

1.96 (0.23)

2.31 (0.16)

Mean medial parietal VOI CT (mm)

2.06 (0.19)^#

2.33 (0.13)

-

-

1.98 (0.21)

2.3 (0.14)

Mean frontal VOI CT (mm)

2.42 (0.13)

2.56 (0.11)

-

-

2.35 (0.14)

2.55 (0.11)