Fig. 8
Microglial response to chronic antibody treatment. A Immunostaining of Aβ (6E10; green) and microglial marker Iba-1 (red) in cortex from representative CD4+ T cell depleted AppNL−G−F mice treated with PBS, low (6.4 nmol/kg) or high (32 nmol/kg) dose of RmAb158-scFv8D3, or with RmAb158 (32 nmol/kg). B Merged images of Aβ and Iba-1 staining of individual Aβ deposits in the cortex of the same mice as in A. C ELISA quantification of sTREM2 in TBS 16 K extracts from the cortex of treated mice. Values are mean and error bars represent standard deviation