Fig. 7
Aβ quantification after chronic antibody treatment. Concentrations of soluble Aβ aggregates in TBS 16 K extracts (A) and of total Aβ1–42 in FA soluble extracts (B) of cortex, hippocampus, and cerebellum from CD4+ T cell depleted AppNL−G−F mice treated with PBS, low (6.4 nmol/kg) or high (32 nmol/kg) dose of RmAb158-scFv8D3, or with RmAb158 (32 nmol/kg). C Representative images of Aβ42 immunostaining in the cortex and hippocampus from antibody-treated AppNL−G−F mice. D Quantification of Aβ42 immunostaining in the cortex and hippocampus of antibody-treated AppNL−G−F mice