Fig. 4

CD4⁺ T cell depletion in wt mice. A. Study design: 4-month-old wt mice were injected with anti-CD4 antibody GK1.5 at 167 nmol/kg body weight to deplete them from CD4⁺ T cells. After 24 h, a tracer dose of [¹²⁵I]GK1.5 was injected in CD4⁺ T cell depleted and naïve mice to image any remaining CD4⁺ T cells. Blood pharmacokinetics (B), distribution to organs (C), and SPECT imaging (D) of [¹²⁵I]GK1.5 in CD4⁺ T cell depleted (n = 2) and naïve (n = 2) wt mice 24 h after injection. A was created with BioRender