Fig. 3

Longitudinal tau PET images from a selection of ADAD family members. The images have been smoothed with a Gaussian kernel (full-width at half maximum = 3 mm) in order to provide easier visual interpretation. The first two columns represent three cardinal slice views on the precuneus at baseline and follow-up time points. All of these SUVR images are mapped to the same colour scale. The third column represents the difference image between the two time points, with warm colours showing an increase in tau deposition and cool colours representing a decrease