Spatial navigation is associated with subcortical alterations and progression risk in subjective cognitive decline

Table 4 Right hippocampal subfield volumes (mm³)

	NC (n = 77)	G-SCD (n = 40)	B-SCD (n = 40)	MCI (n = 23)	F	P
Tail	533.30 ± 68.27	541.56 ± 73.41	521.76 ± 77.54	494.31 ± 68.98	1.651	0.180
Subiculum	405.03 ± 48.60	407.07 ± 50.87	398.36 ± 47.67	368.83 ± 47.03^cef	3.168	0.026*
CA1	599.83 ± 77.12	590.84 ± 78.50	571.73 ± 69.33	539.58 ± 59.69^c	3.776	0.012*
Fissure	174.85 ± 34.63	168.29 ± 29.36	164.64 ± 30.02	154.86 ± 24.73	2.287	0.080
Presubiculum	281.58 ± 29.56	278.40 ± 33.66	278.86 ± 30.81	256.79 ± 38.83^cf	3.433	0.018*
Parasubiculum	52.84 ± 9.26	51.21 ± 8.47	52.46 ± 9.98	49.38 ± 7.39	0.917	0.434
Molecular layer	528.53 ± 58.90	525.75 ± 62.01	512.38 ± 53.09	474.96 ± 54.67^cef	4.899	0.003*
Dentate gyrus	270.86 ± 34.67	264.55 ± 30.37	260.47 ± 27.93	242.87 ± 28.10^cef	4.403	0.005*
CA2/3	185.85 ± 30.40	186.76 ± 28.44	179.64 ± 25.24	166.14 ± 25.92	2.611	0.053
CA4	229.72 ± 29.34	224.50 ± 25.27	222.68 ± 24.02	207.10 ± 22.62^cf	3.974	0.009*
Fimbria	72.61 ± 17.86	64.33 ± 13.40^a	65.69 ± 15.80^b	64.57 ± 18.49	3.677	0.013*
HATA	55.43 ± 8.44	54.19 ± 9.15	53.15 ± 9.60	48.61 ± 8.14^c	3.124	0.027*

Data were presented as means ± standard deviation
^*p < 0.05, FDR corrected, controlling for sex, age, years of education, and total intracranial volume
^a~fPost hoc analyses showed a significant difference between groups. ^aNC vs G-SCD; ^bNC vs B-SCD; ^cNC vs MCI; ^dG-SCD vs B-SCD; ^eG-SCD vs MCI; ^fB-SCD vs MCI

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