Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer’s disease

Table 2 Results of EWAS using AD case–control status in Oxford sample

Position	Gene	CpGs	p-value	p_adj	Previous studies (ref.)^a
chr1:2,004,968–2,005,180	PRKCZ	3	4.50E-11	1.41E-07
chr15:22,921,227–22,921,426	CYFIP1	3	4.75E-10	1.59E-06	DMR in CYFIP1 [16]
chr1:6,445,901–6,445,975	ACOT7	3	3.80E-10	3.42E-06
chr13:110,918,122–110,918,331	COL4A1	3	1.82E-09	5.80E-06
chr1:228,362,233–228,362,309	IBA57 / C1orf69	3	6.03E-08	5.30E-04	IBA57 previously described [18]

AD case–control DMRs identified using p-comb software. CpGs number of CpGs in each DMR, p_adjp-value after adjustment for multiple testing based on the Sidak method
^aEvidence for implication of same or largely overlapping locus from studies using DNAm assessments in AD-related phenotypes. More (p < 1.00E-05) results from this analysis can be found in Supplementary Table 1 and 2

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