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Table 3 The median years to estimated clinical onset (YECO) for each test in MCI and AD patients subdivided according to beta-amyloid abnormality (yes vs no). P-values for two-way (diagnostic group and amyloid abnormality) ANOVAs

From: A biomarker-validated time scale in years of disease progression has identified early- and late-onset subgroups in sporadic Alzheimer’s disease

Cognitive test, YECO

YECO

p

MCI

AD

PiB + 

PiB − 

PiB + 

PiB − 

D

A

DxA

Similarities

 − 4.1

 − 11.5

 ± 0.0

 − 4.8

*

**

ns

Block Design

 − 1.7

 − 3.4

 + 4.9

 + 1.8

***

ns

ns

RAVL learning

 − 1.4

 − 6.6

 + 2.7

 + 0.7

**

*

ns

RO retention

 − 4.0

 − 8.6

 + 4.1

 − 0.3

***

ns

ns

Digit Symbol

 + 1.4

 − 5.1

 + 4.8

 − 1.1

ns

*

ns

Mean YECO

 − 1.2

 − 5.51

 + 3.8

 + 0.5

***

**

ns

  1. A, amyloid abnormality (yes vs no); D, diagnostic group; DxA, diagnostic-by-amyloid abnormality subgroup interaction; ns, nonsignificant; RAVL, Rey auditory verbal learning; RO, Rey-Osterrieth
  2. * p < 0.05; ** p < 0.01; *** p < 0.001