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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Functional gradients of the medial parietal cortex in a healthy cohort with family history of sporadic Alzheimer’s disease

Fig. 5

Immediate memory is associated with the gradient functional parameters from the fMRI task-based encoding task. Scatter plots showing significant associations between RBANS immediate memory scores and relevant trend surface model parameters (A). Two individual participants with high and low memory scores are circled in different colors in the scatter plots (A) and their representative functional gradients are shown below (B) with black arrows highlighting where the main differences lie between the two participants (namely, participants with better memory performance exhibited a more evenly distributed gradient with similar stepwise changes in functional profiles across the medial parietal cortex — similarly to resting state gradients in participants with lower CSF marker levels — whereas the gradient was steeper in the middle portion for participants with lower memory scores, essentially partitioning the medial parietal cortex into two functionally distinct clusters). The histograms next to the gradients depict the distribution of voxels along the gradient scale

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