Fig. 4

Differences in the main resting-state medial parietal gradient parameters between ApoE ε4 allele carriers and noncarriers. Boxplots showing the different trend surface model parameters (describing spatial variation in the gradients) in the ApoE ε4 carrier and noncarrier groups (A) and parameters showing significant differences after correcting for the effects of age, sex, education, and multiple comparisons between groups (B). Surface projections of the dominant gradient in a representative ApoE ε4 noncarrier and a ApoE ε4 carrier participant with black arrows highlighting where the main differences lie between the two participants (B). The color bars besides the projections denote normalized gradient values, whereas the histograms depict the distribution of voxels along the gradient scale (C). Plots depicting gradient values along the inferior-superior axis after projection to a streamline of the gradient field for a ApoE ε4 noncarrier and a ApoE ε4 carrier participant (D). Abbreviations: TSM, trend surface model; ε4 − , ApoE ε4 noncarrier; ε4 + , ApoE ε4 carrier