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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Functional gradients of the medial parietal cortex in a healthy cohort with family history of sporadic Alzheimer’s disease

Fig. 1

A schematic representation of the connectopic mapping procedure. After the delineation of the region of interest and target mask, functional connectivity was computed between the ROI and target mask voxels (Step 1), which resulted in a functional connectivity matrix, i.e., connectivity fingerprint for each ROI voxel (Step 2). These fingerprints are then compared, and a similarity matrix is built using the eta-squared distance measure (Step 3). Finally, the Laplacian eigenmap algorithm is used to decompose the graph-transformed similarity matrix, obtaining functional gradients (Step 4). Abbreviations: MPC, medial parietal cortex

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Alzheimer's Research & Therapy

ISSN: 1758-9193