Fig. 5From: Plasma β2-microglobulin and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE studyMediation analyses of AD biomarkers between B2M and cognition. Mediation analyses with 10,000 bootstrapped iterations were used to examine the mediation effects of Aβ pathologies on cognition. Aβ1–42, Aβ1–42/Aβ1–40, and P-tau/Aβ1–42 mediated the relationship between B2M and MMSE (A–C). Aβ1–42, P-tau/Aβ1–42, and T-tau/Aβ1–42 mediated the relationship between B2M and MoCA (D–F). Each model path was adjusted for age, sex, years of education, APOE ε4 status, and MMSE. a is the effect of the independent variable on mediators; b is the effect of mediators on dependent variables after controlling the influence of independent variables; c is the total effect of independent variables on dependent variables; c′ is the direct effect. Abbreviations: B2M, β2-microglobulin; P-tau, phosphorylated tau protein; T-tau, total tau protein; Aβ, amyloid β; APOE, apolipoprotein EBack to article page