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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Plasma β2-microglobulin and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE study

Fig. 5

Mediation analyses of AD biomarkers between B2M and cognition. Mediation analyses with 10,000 bootstrapped iterations were used to examine the mediation effects of Aβ pathologies on cognition. Aβ1–42, Aβ1–42/Aβ1–40, and P-tau/Aβ1–42 mediated the relationship between B2M and MMSE (AC). Aβ1–42, P-tau/Aβ1–42, and T-tau/Aβ1–42 mediated the relationship between B2M and MoCA (DF). Each model path was adjusted for age, sex, years of education, APOE ε4 status, and MMSE. a is the effect of the independent variable on mediators; b is the effect of mediators on dependent variables after controlling the influence of independent variables; c is the total effect of independent variables on dependent variables; c′ is the direct effect. Abbreviations: B2M, β2-microglobulin; P-tau, phosphorylated tau protein; T-tau, total tau protein; Aβ, amyloid β; APOE, apolipoprotein E

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