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Table 3 Top 10 most significant CpGs associated with CSF phosphorylated tau181 (pTau181) in cognitively normal (CN) and Alzheimer’s disease (AD) subjects. Annotations include the location of the CpG based on hg19/GRCh37 genomic annotation (chr, position) and nearby genes based on GREAT (GREAT_annotation). Regression analysis results for CpG-to-CSF pTau181 association include effect estimate, standard error (se), and P-values after inflation correction using the bacon method (PMID: 28129774). Highlighted in red are gene promoter regions mapped to significant CpGs

From: Distinct CSF biomarker-associated DNA methylation in Alzheimer’s disease and cognitively normal subjects